Protein Alignment nAChRbeta2 and lgc-7

DIOPT Version :9

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_502777.2
• Gene: lgc-7 / 190370
• WormBaseID: WBGene00013300
• Length: 439
• Species: Caenorhabditis elegans
• Alignment Length: 460
• Identity: 116/460 - (25%)
• Similarity: 208/460 - (45%)
• Gaps: 57/460 - (12%)

  Fly    31 KRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYKLRWDP 95
            ::|.|.|:..|:..||||.|..:.|.:.:.:....::.::...:.:..:.....:|.|..|.|:.
 Worm    29 EQLKDVLMEGYDSSIRPVNNERDILIINISMNTMSVLTLDPAEETINFSSEFILQWKDEFLFWNK 93

  Fly    96 EEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTK-ATLKYTGEVFWEPPAIYKSSCEMNVE 159
            .:| .:..|.:....:|.||..:..:.|.||.:....: .::|:.|.|.....|::.:.|:|||:
 Worm    94 SDY-NITWLKLKESFLWTPDTTVSTSIDTNYLIDASERYVSVKHDGTVRQSIYAVFTNLCDMNVD 157

  Fly   160 YFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDLTEFYLSVEWDILEVPATKNEEY 224
            .||||:|.|.:|.|.|:|...:|..     |.|.::.....|..:|:.:.|||...:.::..|..
 Worm   158 KFPYDQQTCMIKMGPWSYTTQEVTC-----IVGRDIAPNDTDFGDFHGNSEWDFEGIVSSVGETE 217

  Fly   225 YPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDS----GEKVTLCISILV 285
            .||....||::.|.||::|:..||...|::|...:|.:.:...:.|:.:    .|:|.|.|:.|:
 Worm   218 DPDVNFTFSEVHFALTVKRRPQFYVWVLLIPTYIITVVCIFGLFTPTANHGLREERVNLGITTLL 282

  Fly   286 SLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIHFRSPSTHNMSPLVRKLF 350
            |..|...::|..:|.|| .:||||.::|..:.:|::.|...|.||.:|.|: .|....|....|:
 Worm   283 SSAVILQIVANAMPKTS-ELPLLGNFILAEIFVVAIGVLFAVLVLTLHQRA-HTREWRPPAWMLW 345

  Fly   351 LHFMPKLMMMRRTQYTLPDYDDSTPSN-GYTNEIDVRDSISDFPSEFKDSQDGAYDNGMQNSVDS 414
            :..|...........|...:..||... .||.|                   |||
 Worm   346 ILRMTGSSKFLSRNITKIRHKSSTAERIHYTGE-------------------GAY---------- 381

  Fly   415 DNVIPRNLTPEVLQALRAVRFIAQHIKDADKDNEIVEDWKFVSMV--LDRFFLWLFTLSCVFGTL 477
               :.:|| .|.||::|      ::|::.|:|  ...:..:|...  ||...|::|.:.....||
 Worm   382 ---LFKNL-DESLQSVR------EYIQEEDRD--YFRELTYVKFFDRLDFLLLFIFQVGNALVTL 434

  Fly   478 AIICQ 482
            .::.|
 Worm   435 FLVKQ 439

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	115/455 (25%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	57/216 (26%)
lgc-7	NP_502777.2	LIC	6..437	CDD:273305	115/456 (25%)
		Neur_chan_LBD	28..238	CDD:280998	57/214 (27%)
		Neur_chan_memb	245..>349	CDD:280999	30/105 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810