Protein Alignment nAChRbeta2 and lgc-18

DIOPT Version :9

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_510029.3
• Gene: lgc-18 / 187977
• WormBaseID: WBGene00011360
• Length: 399
• Species: Caenorhabditis elegans
• Alignment Length: 374
• Identity: 82/374 - (21%)
• Similarity: 163/374 - (43%)
• Gaps: 79/374 - (21%)

  Fly    32 RLYDDLLSNYNRLIRPVVNNTE-----------------TLTVWLGLKLSQLIEVNLKNQVMTTN 79
            :|..|:.:||:..:.||....:                 |::::. |||.::||...|..|:
 Worm    36 KLIKDVFTNYDNTLSPVYTKIDPTQPIGYNPLAPKRFNYTVSLYY-LKLVEVIEPEEKVSVV--- 96

  Fly    80 LWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWD-----------------GNYE 127
            |.:.:.|:|.::.||...||.::.|::..:.:|.|.:.|:...|                 |:..
 Worm    97 LEMAEYWYDPRIAWDSSLYGDIKMLHMRQDKVWSPTLSLFRINDIADFRDPDFRMVCVENTGHTY 161

  Fly   128 VTLMTKATLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPG 192
            .||..|.:|                :|.::|..||||.|.|.::|        .:.|..:.|:..
 Worm   162 TTLSVKISL----------------NCPLDVSMFPYDSQTCRIQF--------NMPLFFMQQVEM 202

  Fly   193 SNLVQVGI---DLTEFYLSVEWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIV 254
            .:.:..||   .:.|...:.||::..:..:.....|.|.|......||::.:||..::|...:|.
 Worm   203 FSQIYEGILNSTVWEKMGNSEWELANLTHSVELLSYGDGLGDMQLATFEIRIRRNPMYYIYMIIF 267

  Fly   255 PCVALTFLTVL-VFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMIL 318
            |...:..|::: ||...:|...|:.:.::.::::|....::|:.||.|. ::||||.|::..:.:
 Worm   268 PSFIINALSIIGVFLKKTDKMSKLNVGLTNIMTMTFILGVMADKIPKTG-SIPLLGIYIIVNLFI 331

  Fly   319 VSLSVWTTVCVLNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRRTQYTL 367
            :.::|..|:.:..|.      ....|.:||      .|..|.::.:|.|
 Worm   332 MIVAVGLTIVLAEIQ------KCAIPKLRK------NKSKMNQKLEYVL 368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	82/374 (22%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	54/251 (22%)
lgc-18	NP_510029.3	LGIC_ECD_cation	75..257	CDD:349790	47/209 (22%)
		LGIC_TM_cation	259..>341	CDD:349853	20/82 (24%)
		TM1 helix	263..284	CDD:349853	5/20 (25%)
		TM2 helix	292..313	CDD:349853	2/20 (10%)
		TM3 helix	323..341	CDD:349853	3/17 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810