Protein Alignment nAChRbeta2 and lgc-17

DIOPT Version :9

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_510028.2
• Gene: lgc-17 / 187976
• WormBaseID: WBGene00011359
• Length: 401
• Species: Caenorhabditis elegans
• Alignment Length: 361
• Identity: 80/361 - (22%)
• Similarity: 155/361 - (42%)
• Gaps: 83/361 - (22%)

  Fly    36 DLLSNYNRLI----------RPVVNNTETLTVW---LGLKLSQLIEVNLKNQVMTTNLWVKQRWF 87
            ||.:||:..|          .|..|:|.|:..|   :.|...:|:||....:.::..|.:.::|:
 Worm    42 DLFANYDPTISSVYSSSFDYEPSHNHTRTVDRWNYTILLYYLKLVEVQEPEEKVSVVLELVEQWY 106

  Fly    88 DYKLRWDPEEYGGVEQLYVPSEHIWVP--------DIVLYNNWD---------GNYEVTLMTKAT 135
            |.:|.|:...|..:..::|..|.:|.|        :|:.:.:.|         |..:..|..:.:
 Worm   107 DPRLSWNSSLYSNIPTVFVRQEKVWSPTLSAFGVNEIIDFRDQDFRIVSIDDIGYIQDYLSVRVS 171

  Fly   136 LKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGI 200
                            |:|.|:|..||:|.|.|.:.|                .:|..|:.||.|
 Worm   172 ----------------SNCPMDVSRFPFDSQTCQICF----------------CLPIFNIRQVKI 204

  Fly   201 DLTEFYLSV------------EWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLI 253
             |.|.|..:            ||.::.:.....:..|.|.........|::|:||..|:|...::
 Worm   205 -LNEIYEGILQEKIIKTMGNSEWKVVSLTNRVEQLKYDDDYGNMDLAVFEITIRRNPLYYIYMIV 268

  Fly   254 VPCVALTFLTVLVFYLPS-DSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMI 317
            .|...:..::::..:|.| |...|:.:.::.::::|....::|:.||.|. ::||||.|::..::
 Worm   269 FPSFVINGISIVGIFLKSADKMSKLNVGLTNIMTMTFILGVMADKIPRTG-SIPLLGIYIIINLL 332

  Fly   318 LVSLSVWTTVCVLNIHFRSPSTHNM----SPLVRKL 349
            ::.:::  ||.||....|..:...:    |.:.|||
 Worm   333 IMIIAI--TVVVLITELRQWAVPRLKLKKSYISRKL 366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	80/361 (22%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	54/252 (21%)
lgc-17	NP_510028.2	LGIC_ECD_cation	77..259	CDD:349790	43/214 (20%)
		LGIC_TM	261..>317	CDD:365787	11/55 (20%)
		TM1 helix	261..286	CDD:349850	4/24 (17%)
		TM2 helix	294..315	CDD:349850	2/20 (10%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810