Protein Alignment nAChRbeta2 and lgc-16

DIOPT Version :9

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_510027.2
• Gene: lgc-16 / 187975
• WormBaseID: WBGene00011358
• Length: 401
• Species: Caenorhabditis elegans
• Alignment Length: 357
• Identity: 80/357 - (22%)
• Similarity: 159/357 - (44%)
• Gaps: 65/357 - (18%)

  Fly    31 KRLYDDLLSNYNRLI----------RPVVNNTETLTVW---LGLKLSQLIEVNLKNQVMTTNLWV 82
            :.|.:||.:||:..|          .|:.:|..|:..|   :.|...:|:||....:.::..|.:
 Worm    37 ENLTNDLFANYDPTISTVYADIADWEPLGDNPRTIDRWNYTILLYYLKLVEVQEPAEKVSVVLEL 101

  Fly    83 KQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVP--------DIVLYNNWDGNYEVTLMTKATLKYT 139
            .:||:|.:|.|:...|..|..::...|.:|.|        :|:.:.:.|       ....::.:|
 Worm   102 VERWYDPRLSWNISLYSNVSTIFARQEKVWSPTLSPFGVNEIIDFRDQD-------FRLISIDFT 159

  Fly   140 GEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDLTE 204
            |.:.........::|.|:|..||:|.|.|.::|                .:|..|:.||.| |.|
 Worm   160 GYLNDYLSVRVSANCPMDVSRFPFDSQTCQIRF----------------CLPIFNIRQVKI-LNE 207

  Fly   205 FYLSV------------EWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCV 257
            .|..:            ||.::.:.....:..|.|.........|::|:||..|:|...::.|..
 Worm   208 IYEGILQEKIIKTMGNSEWKVVSLTNRVEQLKYDDDYGNMDLAVFEITIRRNPLYYIYMIVFPSF 272

  Fly   258 ALTFLTVLVFYLPS-DSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSL 321
            .:..::::..:|.| |...|:.:.::.::::|....::|:.||.|. ::||||.|::..::::.:
 Worm   273 VINGISIVGIFLKSADKMSKLNVGLTNIMTMTFILGVMADKIPRTG-SIPLLGIYIIINLLIMII 336

  Fly   322 SVWTTVCVLNIHFRSPSTHNM----SPLVRKL 349
            ::  ||.||....|..:...:    |.:.|||
 Worm   337 AI--TVVVLITELRQWAVPRLKLKKSYMSRKL 366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	80/357 (22%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	54/248 (22%)
lgc-16	NP_510027.2	LGIC_ECD_cation	77..259	CDD:349790	43/205 (21%)
		LGIC_TM	261..>317	CDD:365787	11/55 (20%)
		TM1 helix	261..284	CDD:349850	3/22 (14%)
		TM2 helix	291..315	CDD:349850	3/23 (13%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810