Protein Alignment nAChRbeta2 and lgc-12

DIOPT Version :9

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_498656.3
• Gene: lgc-12 / 187855
• WormBaseID: WBGene00020048
• Length: 428
• Species: Caenorhabditis elegans
• Alignment Length: 494
• Identity: 131/494 - (26%)
• Similarity: 219/494 - (44%)
• Gaps: 125/494 - (25%)

  Fly    16 ANSTAPISF-EANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTN 79
            :|.|..|.: |.|  .:.|...|:.:|.:..|||.|.:..|||.:..::..|:|||.:|:.:...
 Worm    16 SNFTIEIEYPEIN--ERELVKHLMKDYYQFTRPVKNYSSMLTVTIMPQIYNLVEVNEQNEQIKLL 78

  Fly    80 LWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWD-----GNYEVTLMTKATLKYT 139
            :|..|.|.|..|.|||:|:.|:|::.:|...:|:||..::|..:     .|:.|      .:.|.
 Worm    79 IWFPQSWKDDYLVWDPDEWDGIEKITIPKSMVWLPDGYIFNTVEETDTLDNHNV------RVHYN 137

  Fly   140 GEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDLTE 204
            |:|..:...:....|.|:|..||:|.|:|.::||||||....:..         |:::..::  |
 Worm   138 GKVEVDFNKLIDLICPMSVLSFPFDVQLCALQFGSWTYQSHALSF---------NVLEASVN--E 191

  Fly   205 FYLSVEWDILEVPATKNEEYYPDTL---EPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLV 266
            ...:.||||:...|||....|.:.:   ..:.:|.:.|.:|||.|:|.|.:::|    |||.|.|
 Worm   192 NNKNSEWDIVAFNATKKVSKYMNLIGGDNVYEEIFYFLEVRRKPLYYIVVILIP----TFLIVTV 252

  Fly   267 ----FYLP----SDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSV 323
                .:.|    .|..|.|:|.::.::::.|...::...:|.:|..:||||.|:|....|..::|
 Worm   253 SNIGLFTPHGVHGDREEHVSLGLTTMLTMAVILDMVTGQMPKSSEGIPLLGMYVLIEFALSIMAV 317

  Fly   324 WTTVCVLNIHFRSPSTHNMSPLVRKLFLHFMP-----KLMMMRRTQYTLP--DYDDSTPSNGYTN 381
            ..:|.::..|            .|.|::..||     :|....:.|..|.  :||
 Worm   318 LVSVLIIFAH------------ERMLYMDAMPPFWIFRLFSKHKNQIPLAEMEYD---------- 360

  Fly   382 EIDVRDSISDFPSEFKDSQDGAYDNGMQNSVDSDNVIPRNLTPEVLQALRAVRFIAQHIKDAD-K 445
              |:|.|                              |.:|..|:...:..||   :|::|.| |
 Worm   361 --DLRSS------------------------------PVDLAQELRFCIEKVR---KHLEDLDSK 390

  Fly   446 D-NEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAIICQS 483
            | ||::  |:       |||      ||.    .|||.|
 Worm   391 DKNELI--WQ-------RFF------SCA----DIICGS 410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	127/488 (26%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	65/225 (29%)
lgc-12	NP_498656.3	Neur_chan_LBD	29..235	CDD:280998	64/222 (29%)
		Neur_chan_memb	242..>345	CDD:280999	28/118 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810