Protein Alignment nAChRbeta2 and acr-20

DIOPT Version :9

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_001367183.1
• Gene: acr-20 / 187632
• WormBaseID: WBGene00000059
• Length: 556
• Species: Caenorhabditis elegans
• Alignment Length: 540
• Identity: 141/540 - (26%)
• Similarity: 237/540 - (43%)
• Gaps: 112/540 - (20%)

  Fly    29 DTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYKLRW 93
            |...:.:.:|..||..:.|.:.....:.|...::|.|:|.||...|.:..|.||.:||.|..|.|
 Worm    23 DQYEIANKILDKYNAGLIPSMGKKSPIEVHFSMELYQIISVNEPQQFLMLNAWVVERWTDRLLGW 87

  Fly    94 DPEEYGGVEQLYVPSEHIWVPDIVLYNNW----DGNYEVTLMTKATLKYTGEVFWE--PPAIYKS 152
            |||::|.|.::.:|...||:||..|||:.    |.|..:......||......|.|  .|.|||.
 Worm    88 DPEKFGNVTEIMLPHHFIWLPDTTLYNSLVMKDDENRRLLHAKVTTLGEGNGAFIELLYPTIYKL 152

  Fly   153 SCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDLTEFYLSVEWDILEVP 217
            ||.:|:.:||:|.|.|.:.|||||::..::|....::       ...|..|....:..|::|...
 Worm   153 SCLLNLRFFPFDVQSCRLLFGSWTFDNTKIDYFAFNE-------SQAIGTTNCIENEGWNVLSTS 210

  Fly   218 ATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDSG----EKVT 278
            ..::|..|......::.:.|:||::||.|:|.:|||:|...:||::::.|:..|...    ||:|
 Worm   211 VIRHENKYDCCPNNYTLLEFRLTIQRKPLYYIINLIIPTSIITFISIIGFFSTSSINEPREEKIT 275

  Fly   279 LCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVC---VLNI----HFRS 336
            |.|:.|:|:::...::::.:|.||..:||:|.:....::|:|.|   |:|   |:.:    :..:
 Worm   276 LGITTLLSMSILIFMVSDKMPSTSSFIPLIGLFYTSMILLISFS---TICSSVVIYVQKQGNLGN 337

  Fly   337 PSTHNMSPLVRKL--FLHF-MPKLM-----------MMRRTQ-----------YTL-------PD 369
            |.:.|...:.|.:  |:.. ||.:|           .:||.|           |.|       .|
 Worm   338 PPSKNFMNIARAVNRFIRMEMPLIMKQAYAQKAREEKLRRQQMGRKQSLWTRVYKLAREQALRKD 402

  Fly   370 YDDSTPSNGYTNEIDVRDSISDFPSE----FKD----SQDGAYDNGMQN--SVDSD---NVIPRN 421
            ...|..|:.: ||:...:.:.|...:    .||    |..|....|:..  |.|.|   :::...
 Worm   403 VQTSQNSSKF-NEVLTPEKLIDNGGKRCTINKDVTCISDSGIVAMGVPTLASEDDDQDVSLLELE 466

  Fly   422 LTP---------------------------EVLQALRAVRFIAQHIKDADKDNEIVEDWKFVSMV 459
            .||                           ||..:.|..|.:|          ||..||  ::.:
 Worm   467 TTPTPAMQRPTRLHKASTCGSFDSMMFRQIEVPVSPRTARNLA----------EIEYDW--LAAL 519

  Fly   460 LDRFFLWLFTLSCVFGTLAI 479
            |:|.||..|....|..::.|
 Worm   520 LERIFLITFLFIFVLTSIGI 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	140/538 (26%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	68/223 (30%)
acr-20	NP_001367183.1	Neur_chan_LBD	24..238	CDD:397192	66/220 (30%)
		LGIC_TM_cation	239..>329	CDD:349853	29/92 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010