Protein Alignment nAChRbeta2 and lgc-30

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_500015.3
• Gene: lgc-30 / 186551
• WormBaseID: WBGene00019069
• Length: 529
• Species: Caenorhabditis elegans
• Alignment Length: 496
• Identity: 118/496 - (23%)
• Similarity: 220/496 - (44%)
• Gaps: 84/496 - (16%)

  Fly    26 ANPDTK-----RLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQR 85
            |:||..     ||...:.|:....| |:.:....:.|::...|.|:::::.:|.:.|.:.::...
 Worm    57 ADPDADGDPHGRLATWIRSHARHHI-PLKHPHTRIDVFISAGLYQIVDLDQRNNLATVSAYLDVH 120

  Fly    86 WFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNY-EVTLMTKATLKYTGEVFWEPPAI 149
            |.|..::|.||.:||:|:::||.:.||.|:..:|::..|.. :......|.|.|.|.|.......
 Worm   121 WNDDFIKWKPEIFGGIERIFVPIKWIWKPEFYMYHSVYGRVPDYAPDASAELHYNGLVRMFVSIS 185

  Fly   150 YKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDLTEFYLSVEWDIL 214
            .||.|.:|.:.||:|.|.|....|||.|....|:|....|         .|.|.:||.:.||.:.
 Worm   186 SKSFCPINFKRFPFDSQTCSFSCGSWAYQSNIVNLVAAKQ---------EIALEDFYDNQEWLLT 241

  Fly   215 EV----PATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDS-- 273
            :.    ..|:|   .....|.||.:..:|.::|::.:|..||:.|...::.:.|:.|:.|.::
 Worm   242 DARLFNGTTRN---VSAANESFSMVYMQLDLKRQSFYYVFNLVFPTTLVSLVAVIGFHAPINATG 303

  Fly   274 --GEKVTLCISILVSLTVFFLLLA-------EIIP---PTSLAVPLLGKYLLFTMILVSLSVWTT 326
              ..|..|.|..|:|::|..|:|.       |.:|   .:...|||:|.|.:..:.:||::..|:
 Worm   304 RRESKFRLGIMTLLSMSVMLLMLVGEMKFAMESVPGQRGSFSDVPLMGIYYMTLICIVSIATCTS 368

  Fly   327 VCVLNIH---FRSPSTHNMSPLVR-----KLFLHFMPKLMMMRRTQYTLPDY----------DDS 373
            ...:::.   .|:||..::...:|     |||..::||.....:..|:..:.          |.:
 Worm   369 SIFVHLEKFALRNPSWQSVPWYIRWLAAKKLFCCYVPKSFRYDKDAYSRNNNVQAISLHSTPDRN 433

  Fly   374 TPSNGYTNEIDVRDSISDFPSEFKDSQDGAYDNGMQNSVDSDNVIPRNLTPEVLQALRAVRFIAQ 438
            ...|....||:..:...|.|  ..|..:|.   ..:.:...|.::  :|..|::
 Worm   434 VAKNLIPKEINFTEVNQDAP--LHDVLEGP---SAEKTQKIDLIV--SLLREII----------- 480

  Fly   439 HIKD--------ADKDNEIVEDWKFVSMVLDRFFLWLFTLS 471
            |:|:        |...::|:...:.||:   .|:|:|.|::
 Worm   481 HLKERIGASGQLAPYWDQIISRCEKVSL---SFYLFLITIN 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	118/496 (24%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	60/227 (26%)
		Cys-loop	154..168	CDD:349832	6/13 (46%)
lgc-30	NP_500015.3	Neur_chan_LBD	68..272	CDD:460752	58/216 (27%)
		LGIC_TM_cation	274..>374	CDD:349853	25/99 (25%)
		TM1 helix	274..298	CDD:349853	6/23 (26%)
		TM2 helix	310..338	CDD:349853	8/27 (30%)
		TM3 helix	352..374	CDD:349853	4/21 (19%)