Protein Alignment nAChRbeta2 and lgc-6

DIOPT Version :9

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_501410.3
• Gene: lgc-6 / 184621
• WormBaseID: WBGene00017544
• Length: 425
• Species: Caenorhabditis elegans
• Alignment Length: 465
• Identity: 102/465 - (21%)
• Similarity: 215/465 - (46%)
• Gaps: 99/465 - (21%)

  Fly    50 NNTETLTVWLGLKLSQLIEVNLKNQ------VMTTNLWV-----------------KQRWFDYKL 91
            :|||||...|   .:|..:|::|..      .:|.|.::                 ..||:|..|
 Worm    17 SNTETLLQQL---FNQTYDVDMKPSDDLTMVTITPNTFILLSMDQTQETIQYSEEFLLRWYDPIL 78

  Fly    92 RWDPE--EYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTK----ATLKYTGEVFWEPPAIY 150
            .|:..  .|.. :.:.:.:...|:||::..|..|.:   .|:.|    |.|:|.||:....||:.
 Worm    79 HWNQSAVSYEN-DWIKISASRAWIPDVIFTNGIDMD---PLLDKDMQMADLRYNGEIRTSRPAVV 139

  Fly   151 KSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDLTEFYLSVEWDILE 215
            .|.|.:.::.||||.|.|.:..|||.::...:.::       |:.:::......|..:.||:::.
 Worm   140 SSPCPLEIDNFPYDVQKCNISMGSWAFDRRFLSVQ-------SSTIEILPQKGRFEGNSEWELIS 197

  Fly   216 VPATKNEEYYPDTL--EPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDSGE--- 275
            :...:::.|  |||  |.||:||:.:|::||.::|.:.:..|...|..:|:...:.|:.:.:
 Worm   198 ILTVRSDSY--DTLLEEWFSEITYVVTLKRKPVYYVLVIQAPTFILCTITIFGLFTPNSNEDERL 260

  Fly   276 -KVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIHFRSPST 339
             ||.||:::..::::...|:::::|..| .:||||.|::..:.:|:.:...::.:...|
 Worm   261 SKVELCLNMFAAISMMLQLVSDMMPKAS-RLPLLGNYIIAEIFVVTAATIASIIIQQTH------ 318

  Fly   340 HNM--SPLVRKLFLHFMPKLMMMRRTQYTLPDYDDSTPSNGYTNEIDVRD-SISDFPSEFKDSQD 401
            |::  |.:..:.:|..: .|...||.::::.  :.||.|:     :||.: :|..|
 Worm   319 HHVHTSAIRPRRWLRCL-VLCECRRRRFSIS--EASTVSS-----VDVPEHAIQSF--------- 366

  Fly   402 GAYDNGMQNSVDSDNVIPRNLTPEVLQALRAVRFIAQHIKDADKDNEIVEDWKFVSMVLDRFFLW 466
                :.:::|:....|:.|    :.||.:..:           .:|:::  |..:....|...|:
 Worm   367 ----SILKSSLHQTAVLVR----DTLQRMSLI-----------SENQLL--WLKILDKTDLMCLF 410

  Fly   467 LFTLSCVFGT 476
            ||.::.:..|
 Worm   411 LFQVANIVVT 420

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	102/465 (22%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	58/227 (26%)
lgc-6	NP_501410.3	LIC	1..424	CDD:273305	102/465 (22%)
		LGIC_ECD_cation	42..226	CDD:349790	47/196 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810