Protein Alignment nAChRbeta2 and lgc-9

DIOPT Version :9

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_500341.1
• Gene: lgc-9 / 182195
• WormBaseID: WBGene00015412
• Length: 464
• Species: Caenorhabditis elegans
• Alignment Length: 471
• Identity: 106/471 - (22%)
• Similarity: 205/471 - (43%)
• Gaps: 92/471 - (19%)

  Fly    33 LYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYKLRWDPEE 97
            |.:.:...|::.:||...:...:.|.:.:.|..|.||....||.:..:...|:|.|.||.|:|.:
 Worm    44 LIETIQRRYDKRVRPFAESNRPVIVHMTIVLGILTEVRENQQVASFVISHVQKWRDPKLAWNPAD 108

  Fly    98 YGGVEQLYVPSEHIWVPDIVLYNNW-------DGNYEVTLMTKATLKYTGEVFWEPPAIYKSSCE 155
            :.|:.|:.:|...:|||.:.:||:.       |..|:|      .:::||.|....|....:.|.
 Worm   109 HSGLTQVVMPRSLVWVPKLFIYNSMDTKDMLTDDRYDV------RIQHTGHVKVNSPQFVSTLCR 167

  Fly   156 MNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDLTEFYLSVEWDILEVPATK 220
            :|::.||:|.|.|.:...|...:..::|:         |..|..:| :.|..:.||.::.|  |.
 Worm   168 INIDLFPFDTQFCAIALASPLLSVEEMDV---------NATQPPVD-SYFSGNAEWQVMNV--TV 220

  Fly   221 NEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLP-SDSG---EKVTLCI 281
            .:..:.:..|..:::.:.|.:.|:..:|...::||...::.|::|..:.| |:.|   |||:|.:
 Worm   221 KQMKFMEEGEYRAEVHYILHLNRRPTYYITVIVVPTFLISALSILGIFSPGSNDGPRNEKVSLGL 285

  Fly   282 SILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIHFRSPSTHNMSP-- 344
            ..|:::||...::|..:|.:. |:||||.|::..::|.::.|..::.:|::......|..|.|
 Worm   286 GSLLAMTVLLDIVAGAMPKSD-AIPLLGYYIMLVILLCAIGVAVSMAMLSMSRSCIQTSKMPPPH 349

  Fly   345 LVRKLFLHFMPKLMMMRRTQYTLPDYDDSTPSNGYTNEIDVRDSISDFPSEFKDSQDGAYDNGMQ 409
            ..|.|||:....:.                                              .|...
 Worm   350 YYRLLFLNVCRVVK----------------------------------------------QNSGL 368

  Fly   410 NSVDSDNVIPRNLTP----------EVLQALRAVRFIAQHIKDADKDNEIVEDWKFVSMVLDRFF 464
            |.| :.|..|..:||          ::::..||.|...:.|:.....:.:..:|..:...:|.||
 Worm   369 NGV-AMNEKPTAITPRFPDLIAIYNQLIEVARAQRTYRERIEKQKWQHRVEIEWNKIFARIDFFF 432

  Fly   465 LWLFTLSCVFGTLAII 480
            |:||.:   |..|.::
 Worm   433 LFLFEM---FNVLILV 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	106/468 (23%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	53/220 (24%)
lgc-9	NP_500341.1	Neur_chan_LBD	42..245	CDD:280998	53/218 (24%)
		Neur_chan_memb	252..>347	CDD:280999	27/95 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810