DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRbeta2 and acr-12

DIOPT Version :9

Sequence 1:	NP_524483.1	Gene:	nAChRbeta2 / 42920	FlyBaseID:	FBgn0004118	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_510262.1	Gene:	acr-12 / 181475	WormBaseID:	WBGene00000051	Length:	573	Species:	Caenorhabditis elegans

Alignment Length:	577	Identity:	230/577 - (39%)
Similarity:	338/577 - (58%)	Gaps:	93/577 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WHWSLLCVFLLVPLANSTA-PISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQ 65
            ::|:|:   |||.:..:.| .|...|.....:||:|||.:||::.|||.|:::.|||.:|..|.:
Worm    12 FNWALI---LLVAVGGTNAFKIKRTAKDLESQLYEDLLFDYNKVPRPVKNSSDILTVDVGASLIR 73

  Fly    66 LIEVNLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTL 130
            :|:|:.||||:|||||::.:|.|.||.|.||:|||::.|::||:.||.||:|||||..|:.::|:
Worm    74 IIDVDEKNQVLTTNLWLEMKWNDAKLTWTPEKYGGLKTLHIPSDFIWTPDLVLYNNAAGDPDITI 138

  Fly   131 MTKATLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNL 195
            :|.|.:.:.|.|:|:|||||||.|.::|.:||||.|.|.||||:|||.|..||||   |:|...:
Worm   139 LTDALVTFEGNVYWQPPAIYKSFCPIDVTWFPYDSQKCEMKFGTWTYTGRYVDLK---QLPQEEV 200

  Fly   196 V------------QVGIDLTEFYLSVEWDILEVPATKNEEYYPDTLEP--FSDITFKLTMRRKTL 246
            |            |.|:||:.||.|.|||:|.:.:.::...|.....|  :.|||:...:|||||
Worm   201 VTITKDDNDVEFMQQGMDLSFFYRSAEWDLLSLTSERHSVLYASCCGPEKYVDITYYFGLRRKTL 265

  Fly   247 FYTVNLIVPCVALTFLTVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKY 311
            |:|.|||:||..::.||..||||   |..|:|..|||||:||||||:|.:::|||||.:|:.|:|
Worm   266 FFTCNLILPCFLISILTTFVFYL---SDHKITFSISILVTLTVFFLVLIDLMPPTSLVIPMFGRY 327

  Fly   312 LLFTMILVSLSVWTTVCVLNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRRTQYTLPDYDDST-- 374
            |:.|||||:||...:|..:|..|||.|.|.|||.:|.:||.|:||:::|.|     |:..:.|
Worm   328 LITTMILVALSTVVSVITVNFRFRSGSAHKMSPWIRAVFLKFLPKILLMSR-----PEKGEVTKQ 387

  Fly   375 -------------------PSNGYTNEIDVRD----SISDFPSEFKDSQ---DGAYDNGMQNSVD 413
                               .:|.|.|:...::    |:...||    ||   :..:|..|:|
Worm   388 PPLVNAASLVGSNYATAAKAANEYRNKAKGKNNDLMSLRGKPS----SQAVLNNTFDMRMRN--- 445

  Fly   414 SDNVIPRNLTPEV----------------------------LQALRAVRFIAQHIKDADKDNEIV 450
            :|:.:...|.|.:                            :..|..|||||:|.:..:.:.||.
Worm   446 NDSTVENRLKPYLCAQNNNAPTVAFRKTKRQKSKSVDDVVFMNLLNQVRFIAEHFRHNELEGEIS 510

  Fly   451 EDWKFVSMVLDRFFLWLFTLSCVFGTLAIICQSPSLYDTRSPIDRQLSEIPLRKNNF 507
            :||.||:|||||.||.:|::..| ||:.||.:||||||...|::..:...||.:.||
Worm   511 DDWTFVAMVLDRLFLIIFSVLNV-GTVFIILESPSLYDYSKPMNITVPNKPLGQANF 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	215/540 (40%)
nAChRbeta2	NP_524483.1	LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	106/231 (46%)
acr-12	NP_510262.1	LIC	14..539	CDD:273305	217/546 (40%)
		Neur_chan_LBD	38..264	CDD:280998	104/228 (46%)
		Neur_chan_memb	271..538	CDD:280999	99/282 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	1	1.000	-	-		FOG0000583
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920