Protein Alignment nAChRbeta2 and lgc-4

DIOPT Version :9

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_509556.4
• Gene: lgc-4 / 181155
• WormBaseID: WBGene00017580
• Length: 635
• Species: Caenorhabditis elegans
• Alignment Length: 560
• Identity: 150/560 - (26%)
• Similarity: 256/560 - (45%)
• Gaps: 127/560 - (22%)

  Fly    33 LYDDLLSN--YNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYKLRWDP 95
            ||..||.:  |.:.:||.:::::...|..|..|:|::|::.:||.:||..|:...|.|.:|.|:.
 Worm   114 LYRSLLDHTVYEKDVRPCIHHSQPTNVTFGFLLNQIVEMDERNQALTTRSWLNINWMDPRLSWNE 178

  Fly    96 EEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLM-TKATLKYTGEVFWEPPAIYKSSCEMNVE 159
            ..:..::.:|:|...||.|||:|.||....|..:|: |...:...|.|.|...|:::|||.:.|.
 Worm   179 SLWSEIKAIYIPHARIWKPDIILVNNAIREYYASLVSTDVMVTSDGNVTWLFSALFRSSCPIRVR 243

  Fly   160 YFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDLTEFYLSVEWDILEVPATKNEEY 224
            |:|:|:|.|.:||.||:::..:::|       |.| ...| ||:.:..:.|:|::::.|.:....
 Worm   244 YYPFDDQQCDLKFASWSHDITEINL-------GLN-TDKG-DLSSYMNNSEFDLVDMTAVREVVT 299

  Fly   225 YP-DTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDSGEKVTLCISILVSLT 288
            :| ||...:..|..::.|.|:.|||..|.|||||.::.:.||.|.:|.::|||:.:.|:.|:|:.
 Worm   300 FPSDTNSDWPIIVIRIHMHRRPLFYVFNHIVPCVLISSMAVLGFLMPPETGEKINMIITTLLSMG 364

  Fly   289 VFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIH-------------------- 333
            |:...:.|.|||||..|||:|.|.:.::::|.|:....|..||:|
 Worm   365 VYLQSITESIPPTSEGVPLIGMYYVSSLLMVCLATCVNVITLNMHRNGAANQGRHVPAWMQKWIL 429

  Fly   334 ----------FRSP--------STHNMSPLVRKLFLHFMPKLMMMRRTQYTLPDYD--------- 371
                      .|.|        |....|.:.|...|..:.::..|...:....:.:
 Worm   430 GYLATFMRMSIREPDSIALLKASQSKKSTIRRSSILRDLKRVKNMSNVRAKSKEQNANRECECMD 494

  Fly   372 ----------------DSTPSNGYTNEIDVRDSISDFPSEFKDSQDGAYDNGMQNSVDSDNVIPR 420
                            |:.|.||.|    :|:   ||.||          :.....|.||.::||
 Worm   495 PLVHIYAESIMSCLAADTKPMNGST----IRE---DFASE----------STFLGRVVSDGIMPR 542

  Fly   421 ------NLTPEVLQALRAV-----RFIAQH-IKD--ADKDNEIVEDWKFVSMVLDRFFLWLFTLS 471
                  ::..|.....|.:     |.:.|| |::  .|:.:.|...|:.::.|:||..|.||..:
 Worm   543 ISASSNSVLTEFETRFRRILKRVYRSLQQHEIREEILDERSRIQWQWQQLASVVDRLLLCLFCTA 607

  Fly   472 CVFGTLAIICQSPSLYDTRSPIDRQLSEIPL--RKNNFML 509
            .:|   .|||               |..:|:  |.|:.||
 Worm   608 TLF---TIIC---------------LLIVPVAYRDNDSML 629

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	141/526 (27%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	66/217 (30%)
lgc-4	NP_509556.4	Neur_chan_LBD	111..321	CDD:280998	66/215 (31%)
		Neur_chan_memb	329..>457	CDD:280999	36/127 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810