DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRbeta2 and acr-3

DIOPT Version :9

Sequence 1:	NP_524483.1	Gene:	nAChRbeta2 / 42920	FlyBaseID:	FBgn0004118	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_509129.1	Gene:	acr-3 / 180937	WormBaseID:	WBGene00000043	Length:	487	Species:	Caenorhabditis elegans

Alignment Length:	489	Identity:	178/489 - (36%)
Similarity:	296/489 - (60%)	Gaps:	28/489 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWHWSLLCVFLLVPLANSTAPISFEANPDTKRLYDDLLSNYNRLIRPVVN-NTETLTVWLGLKLS 64
            :|.:|::.:||:..|  ...|.|.|     :||...:...||.|||||:| ::..:.|:..|...
Worm     4 IWLFSIITIFLITEL--QCYPNSAE-----ERLLSYIFDGYNSLIRPVLNASSPPIEVFFSLAFV 61

  Fly    65 QLIEVNLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVT 129
            .||.|:.|||:|.||:|...:|.||:::|||.|:.|::.:.||.:.:|:|||||:||.||||.|:
Worm    62 LLINVDEKNQIMQTNVWPTMKWNDYQMQWDPREFDGIKTIRVPPDKVWLPDIVLFNNADGNYLVS 126

  Fly   130 LMTKATLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSN 194
            ..:...:::||::.|.|||:|||||.::||:||:|||:|.:.|||||:...::.|.:|.   |..
Worm   127 FYSNVVVEHTGDMLWVPPAVYKSSCLIDVEFFPFDEQVCSLTFGSWTFRKDELQLSYLS---GKR 188

  Fly   195 LVQVGIDLTEFYLSVEWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVAL 259
                .::|.::..|..||:::.|....:|.        |.|::::.:|||.|||||.||:|.|.:
Worm   189 ----HVELNDYLPSGVWDLIDAPGLLIDER--------SKISYQIKIRRKALFYTVILIMPTVLM 241

  Fly   260 TFLTVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVW 324
            .||:::|||||::|.||:||.||||::|.||.|::::|:||||..:||:.||||.|.|:..:::.
Worm   242 AFLSMMVFYLPAESSEKITLAISILLALVVFLLVVSKILPPTSSTIPLMAKYLLMTFIMNMITIM 306

  Fly   325 TTVCVLNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRRTQYTLPDYDDSTPSNGYTNEIDVRDSI 389
            .:|.::|::||.|:||.|...|:.:||.|:|.|.:|||     |:..:...:.....:.:.|...
Worm   307 VSVIIINVYFRGPATHIMPNWVKTVFLKFLPVLFVMRR-----PESTEKELAKMKREKRERRSMK 366

  Fly   390 SDFPSEFKDSQDGAYDNGMQNSVDSDNVIPRNLTPEVLQALRAVRFIAQHIKDADKDNEIVEDWK 454
            |...:.||.:.....:...|.|....:.....|:.:..:|:.|:.:|..|:...:......|:||
Worm   367 SALKTFFKRNDAKISEQPKQTSRKDGSSSEEKLSSDAKKAIEAIEYITTHLTHDNAFKRQREEWK 431

  Fly   455 FVSMVLDRFFLWLFTLSCVFGTLAIICQSPSLYD 488
            |||:|:||..|:||......||:.|:..:|::::
Worm   432 FVSVVIDRLLLYLFFAVTTGGTVGILLSAPNVFE 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	174/470 (37%)
nAChRbeta2	NP_524483.1	LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	83/218 (38%)
acr-3	NP_509129.1	LIC	5..460	CDD:273305	177/481 (37%)
		Neur_chan_LBD	26..226	CDD:280998	82/219 (37%)
		Neur_chan_memb	234..456	CDD:280999	80/226 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820