Protein Alignment nAChRbeta2 and acr-2

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_509128.1
• Gene: acr-2 / 180936
• WormBaseID: WBGene00000042
• Length: 575
• Species: Caenorhabditis elegans
• Alignment Length: 535
• Identity: 202/535 - (37%)
• Similarity: 308/535 - (57%)
• Gaps: 70/535 - (13%)

  Fly    29 DTKRLYDDLLSNYNRLIRPVVN-NTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYKLR 92
            |..||..||...||.|||||.| ::..:.|..|:.:..||.|:.|||::.||:|:..:|.|::|.
 Worm    59 DEDRLVIDLFREYNFLIRPVKNVSSPPVVVDFGVAMILLINVDEKNQILQTNVWLTMKWNDFQLA 123

  Fly    93 WDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKATLKYTGEVFWEPPAIYKSSCEMN 157
            |:|.|||.:..|:|||:.:|:|||||:||.||||||:..:...:.:.|:|.|.|||::||||.::
 Worm   124 WNPAEYGNISNLHVPSDRVWLPDIVLFNNADGNYEVSFKSNVFVDHHGDVTWVPPAMFKSSCRID 188

  Fly   158 VEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDLTEFYLSVEWDILEVPATKNE 222
            ||:||:|||.|.:.|||||||..:|.|...:.|.       .:.|.::..|..||:::||.  ..
 Worm   189 VEWFPFDEQCCTLVFGSWTYNSEEVRLHWYNNIQ-------AVQLHDYSYSGIWDVIDVPG--QL 244

  Fly   223 EYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDSGEKVTLCISILVSL 287
            .:.||..|  :.:.|.:.:|||||||||.||:|.|.:.||:|:.||||.||||||:|.||:|::|
 Worm   245 VHKPDLKE--NKMVFNVVIRRKTLFYTVILIIPTVLMAFLSVMAFYLPVDSGEKVSLTISLLLAL 307

  Fly   288 TVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIHFRSPSTHNMSPLVRKLFLH 352
            .||.||:::|:|||| .:||:|||||...:|...:|..||.::||:|||..:|.|...|||:||.
 Worm   308 VVFLLLVSKILPPTS-NIPLMGKYLLLAFVLNITAVVGTVVIVNIYFRSALSHKMPTWVRKVFLE 371

  Fly   353 FMPKLMMMRRTQ-------YTLPDY------------------------------DDSTPSNGYT 380
            |:|.|::|:|.:       |.:.:|                              ..|:.|:|.:
 Worm   372 FLPHLLVMKRPERIPIFNGYFVEEYCASEIFDASLVMPSMTATMLPFLQVTTNLKAASSTSSGQS 436

  Fly   381 NE-----------IDVRDSISDFP-SEFKDSQDGAYDNGMQNSVDSDNVIPRNLTPEVLQALRAV 433
            :|           :.:|.|....| :...|..:...|:...|.|||   :...::.|:...:.|:
 Worm   437 SEHHENCSKWKKRLSIRMSKRRAPRARLDDDSEDIIDDTNGNHVDS---LQEKISKEMKTTVEAI 498

  Fly   434 RFIAQHIKDADKDNEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAIICQSPSLYDTRSPIDRQLS 498
            .:||:|:|......::.:|||:|:|||||..|.:|....:.|||.|||.:|.::|.   :|::
 Worm   499 AYIAEHMKREMSLKKMRDDWKYVAMVLDRLILLIFFGVTLGGTLGIICSAPHVFDF---VDQE-- 558

  Fly   499 EIPLRKNNFMLPPDI 513
            .|..:.|...||.|:
 Worm   559 AIISKLNAKYLPSDM 573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	191/499 (38%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	92/218 (42%)
		Cys-loop	154..168	CDD:349832	8/13 (62%)
acr-2	NP_509128.1	LIC	54..544	CDD:455710	191/499 (38%)
		LGIC_ECD_nAChR_proto_beta-like	59..265	CDD:349833	90/216 (42%)
		Cys-loop	185..199	CDD:349833	8/13 (62%)