Protein Alignment nAChRbeta2 and cup-4

DIOPT Version :9

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_498710.2
• Gene: cup-4 / 176104
• WormBaseID: WBGene00000845
• Length: 433
• Species: Caenorhabditis elegans
• Alignment Length: 375
• Identity: 77/375 - (20%)
• Similarity: 139/375 - (37%)
• Gaps: 91/375 - (24%)

  Fly    33 LYDDLLSNYNRLIRPVVNNTETLTV---WLGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYKLRWD 94
            |...:...||...||:.|.:....|   |..:.:|    :|.:.|.||.:..:..||||..|.||
 Worm    51 LEQKIFRGYNPKNRPMKNASFPTIVDVHWHIIHVS----INQREQTMTVHGHIYMRWFDEFLVWD 111

  Fly    95 PEEYGGVEQLYVPSEHIWVPDIVLYNNWDG---NYEVTLMTKATLKYTG----EVFWEPPAIYKS 152
            |:::..::...|....:|.|.|.:.|:..|   .::.:......::..|    :|...|....|.
 Worm   112 PKDFNNIQYARVKKWQVWQPKIKVSNSASGLGSAFDFSTSAHVIIQMMGKDRAKVEMYPTFSIKV 176

  Fly   153 SCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIP-------------------------- 191
            .|..:...:|||...|.:...| |...|.|.|::|..||
 Worm   177 GCAFDFTDYPYDLNKCAINLFS-TSTMADVQLQNLYAIPPTLSFGWEEQKMKRIISDFKIQNVSS 240

  Fly   192 ------GSNLVQVGIDLTEFYLSVEWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTV 250
                  ..|:.. ...:|.|.|...|.:|.|                 .::|   :|...||...
 Worm   241 SALYYTNGNITS-SAPITGFDLGSTWSMLAV-----------------TVSF---VRHSPLFEAA 284

  Fly   251 NLIVPCVALTFLTVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFT 315
             ::.||:.:..|..:.|::.|.|...:.:.:...|.| :|...|.|.:|.:...:|       |.
 Worm   285 -VVTPCIVVASLISMTFFIDSLSSTFLLMMLHFYVQL-IFLHDLVEKLPLSVSEIP-------FC 340

  Fly   316 MILVSLSVWTTVCVLNIH--------FRSPSTHNMSPLVRKLFL--HFMP 355
            :.|:.:.::|....|.:|        ::.|....::    |:|:  .::|
 Worm   341 IKLIGILMYTNGLTLVLHSSLLCGSYYKCPVPQQLN----KIFVIEEYIP 386

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	77/375 (21%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	53/255 (21%)
cup-4	NP_498710.2	Neur_chan_LBD	48..>222	CDD:280998	44/175 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910