DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRbeta2 and unc-63

DIOPT Version :9

Sequence 1:	NP_524483.1	Gene:	nAChRbeta2 / 42920	FlyBaseID:	FBgn0004118	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_491533.2	Gene:	unc-63 / 172150	WormBaseID:	WBGene00006797	Length:	502	Species:	Caenorhabditis elegans

Alignment Length:	518	Identity:	261/518 - (50%)
Similarity:	352/518 - (67%)	Gaps:	62/518 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 WSLLCVFLLVPLANSTAPISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIE 68
            ::.:.:|||:      :|.: .||.|..||::||:::||:|:|||..|.|||.|...||||||::
Worm     8 FAYILIFLLL------SPPT-HANRDANRLFEDLIADYNKLVRPVSENGETLVVTFKLKLSQLLD 65

  Fly    69 VNLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTK 133
            |:.|||:||||:|::..|.||||||||.||||||.|||||:.||:||:|||||.||||:||:|||
Worm    66 VHEKNQIMTTNVWLQHSWMDYKLRWDPVEYGGVEVLYVPSDTIWLPDVVLYNNADGNYQVTIMTK 130

  Fly   134 ATLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQI-------- 190
            |.|.|.|.|.|.|||||||.|:::||:||:|.|.|.||||||||.|.:|||:|.|:.
Worm   131 AKLTYNGTVEWAPPAIYKSMCQIDVEFFPFDRQQCEMKFGSWTYGGLEVDLQHRDKHLEKEIEED 195

  Fly   191 ------PGSNLVQV---GIDLTEFYLSVEWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTL 246
                  |...:|.|   ||||:::|.|||||||.||..::.:.||....||.|||:::.:|||||
Worm   196 VEGVDGPTKEIVWVVDRGIDLSDYYPSVEWDILNVPGKRHSKRYPCCESPFIDITYEIHLRRKTL 260

  Fly   247 FYTVNLIVPCVALTFLTVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKY 311
            |||||||.|.|.::|||.||||||||.|||::||||||:|||||||||.||||.|||.:||:|||
Worm   261 FYTVNLIFPSVGISFLTALVFYLPSDGGEKISLCISILISLTVFFLLLVEIIPSTSLVIPLIGKY 325

  Fly   312 LLFTMILVSLSVWTTVCVLNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRRTQYTLPDYDDSTPS 376
            |||||:||:|||..||..||:|:|||:||.|...:::||:.|:||.::|.|.|   |....|.|:
Worm   326 LLFTMVLVTLSVVVTVVTLNVHYRSPTTHTMPKWMKRLFVDFLPKYLLMTRPQ---PPGHHSKPN 387

  Fly   377 NGYTNEIDVRDSISDFPSEFKDSQDGAYDNGM-----QNS-----------VDSDNVIPRNLTPE 425
            ..:                  ||:...:..|:     |||           .:|...:||:.:|
Worm   388 RKF------------------DSRASTFSIGVNHVLGQNSELLSPGLNSNREESSFTLPRDNSP- 433

  Fly   426 VLQALRAVRFIAQHIKDADKDNEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAIICQSPSLYD 488
            |..|:.:|.:||.|:|:.:.|.:::||||::|:|:||.||..||.:|.|||:.||.::||:||
Worm   434 VRSAVESVAYIADHLKNEEDDKQVIEDWKYISVVMDRIFLITFTFACAFGTVVIIARAPSIYD 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	255/502 (51%)
nAChRbeta2	NP_524483.1	LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	132/234 (56%)
unc-63	NP_491533.2	LIC	6..487	CDD:273305	255/507 (50%)
		Neur_chan_LBD	29..259	CDD:280998	129/229 (56%)
		Neur_chan_memb	266..487	CDD:280999	111/242 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	297	1.000	Domainoid score	I784
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H134649
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3292
OMA	1	1.010	-	-		QHG45250
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	1	1.000	-	-		FOG0000583
OrthoInspector	1	1.000	-	-		otm14483
orthoMCL	1	0.900	-	-		OOG6_101158
Panther	1	1.100	-	-	LDO	PTHR18945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2381
SonicParanoid	1	1.000	-	-		X294
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.770