Protein Alignment nAChRbeta2 and unc-63

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_491533.2
• Gene: unc-63 / 172150
• WormBaseID: WBGene00006797
• Length: 502
• Species: Caenorhabditis elegans
• Alignment Length: 518
• Identity: 261/518 - (50%)
• Similarity: 352/518 - (67%)
• Gaps: 62/518 - (11%)

  Fly     4 WSLLCVFLLVPLANSTAPISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIE 68
            ::.:.:|||:      :|.: .||.|..||::||:::||:|:|||..|.|||.|...||||||::
 Worm     8 FAYILIFLLL------SPPT-HANRDANRLFEDLIADYNKLVRPVSENGETLVVTFKLKLSQLLD 65

  Fly    69 VNLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTK 133
            |:.|||:||||:|::..|.||||||||.||||||.|||||:.||:||:|||||.||||:||:|||
 Worm    66 VHEKNQIMTTNVWLQHSWMDYKLRWDPVEYGGVEVLYVPSDTIWLPDVVLYNNADGNYQVTIMTK 130

  Fly   134 ATLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQI-------- 190
            |.|.|.|.|.|.|||||||.|:::||:||:|.|.|.||||||||.|.:|||:|.|:.
 Worm   131 AKLTYNGTVEWAPPAIYKSMCQIDVEFFPFDRQQCEMKFGSWTYGGLEVDLQHRDKHLEKEIEED 195

  Fly   191 ------PGSNLVQV---GIDLTEFYLSVEWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTL 246
                  |...:|.|   ||||:::|.|||||||.||..::.:.||....||.|||:::.:|||||
 Worm   196 VEGVDGPTKEIVWVVDRGIDLSDYYPSVEWDILNVPGKRHSKRYPCCESPFIDITYEIHLRRKTL 260

  Fly   247 FYTVNLIVPCVALTFLTVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKY 311
            |||||||.|.|.::|||.||||||||.|||::||||||:|||||||||.||||.|||.:||:|||
 Worm   261 FYTVNLIFPSVGISFLTALVFYLPSDGGEKISLCISILISLTVFFLLLVEIIPSTSLVIPLIGKY 325

  Fly   312 LLFTMILVSLSVWTTVCVLNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRRTQYTLPDYDDSTPS 376
            |||||:||:|||..||..||:|:|||:||.|...:::||:.|:||.::|.|.|   |....|.|:
 Worm   326 LLFTMVLVTLSVVVTVVTLNVHYRSPTTHTMPKWMKRLFVDFLPKYLLMTRPQ---PPGHHSKPN 387

  Fly   377 NGYTNEIDVRDSISDFPSEFKDSQDGAYDNGM-----QNS-----------VDSDNVIPRNLTPE 425
            ..:                  ||:...:..|:     |||           .:|...:||:.:|
 Worm   388 RKF------------------DSRASTFSIGVNHVLGQNSELLSPGLNSNREESSFTLPRDNSP- 433

  Fly   426 VLQALRAVRFIAQHIKDADKDNEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAIICQSPSLYD 488
            |..|:.:|.:||.|:|:.:.|.:::||||::|:|:||.||..||.:|.|||:.||.::||:||
 Worm   434 VRSAVESVAYIADHLKNEEDDKQVIEDWKYISVVMDRIFLITFTFACAFGTVVIIARAPSIYD 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	255/502 (51%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	132/234 (56%)
		Cys-loop	154..168	CDD:349832	7/13 (54%)
unc-63	NP_491533.2	LIC	6..487	CDD:455710	255/507 (50%)
		LGIC_ECD_nAChR_proto_alpha-like	26..261	CDD:349832	132/234 (56%)
		Cys-loop	151..165	CDD:349832	7/13 (54%)