DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRbeta2 and unc-38

DIOPT Version :9

Sequence 1:	NP_524483.1	Gene:	nAChRbeta2 / 42920	FlyBaseID:	FBgn0004118	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_491472.1	Gene:	unc-38 / 172105	WormBaseID:	WBGene00006774	Length:	511	Species:	Caenorhabditis elegans

Alignment Length:	535	Identity:	256/535 - (47%)
Similarity:	345/535 - (64%)	Gaps:	63/535 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WHWSLLCVFLLVPLANSTAPISF----EANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLK 62
            |.:.||.:|.          |||    |.|.|.|||||||:.||||..||..:..:.||:.|.|:
Worm     5 WLFLLLLLFC----------ISFIKLTEGNEDAKRLYDDLMVNYNRHRRPSTSPNKPLTIKLKLR 59

  Fly    63 LSQLIEVNLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYE 127
            |||:|:|:..:|:||.::|:||.|.|.||.|||..||||..||||.|.|||||||||||.|.||.
Worm    60 LSQIIDVHEIDQIMTCSVWLKQTWIDRKLSWDPVNYGGVNVLYVPYEMIWVPDIVLYNNADSNYN 124

  Fly   128 VTLMTKATLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTY--NGAQVDL------ 184
            :|:.|||||.|||||.||||||:||.|:::|.:||:|||.|.:||||||:  |...|:|
Worm   125 ITISTKATLHYTGEVTWEPPAIFKSMCQIDVRWFPFDEQQCHLKFGSWTFSENLLSVELNEPSLR 189

  Fly   185 --KHLDQ---IPGSNLVQVGIDLTEFYLSVEWDILEVPATKNEEYYPDTL--EPFSDITFKLTMR 242
              :.:|:   |....:.:.||||:::|.||||||:...|.:..:.||...  ..:.|:|:.|.:|
Worm   190 YEEEIDEKGIIDNVTVAEDGIDLSDYYPSVEWDIMSRVAKRRAKNYPSCCPQSAYIDVTYYLQLR 254

  Fly   243 RKTLFYTVNLIVPCVALTFLTVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPL 307
            ||.|||||||:.|||.::|||:|||||||||||||||||||||:||:|||||.||||.||:.:||
Worm   255 RKPLFYTVNLVFPCVGISFLTILVFYLPSDSGEKVTLCISILVALTIFFLLLTEIIPATSITLPL 319

  Fly   308 LGKYLLFTMILVSLSVWTTVCVLNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRRTQYTLPDYDD 372
            :||||||||::|:|||..||..||:|||:|:||.|...|:|:||.::|||:.|||
Worm   320 IGKYLLFTMVMVTLSVVVTVISLNLHFRTPTTHLMPNWVKKVFLKWLPKLLFMRR---------- 374

  Fly   373 STPSNGYTNEIDVRDSISDFPSEFKDSQDGA------------YDNGMQNSVDSDNVIPRNLTPE 425
              |.:.|..:.|          :.|..:||.            ..|.::|:...|.:.....:|.
Worm   375 --PIDDYEEKFD----------DKKKPKDGKIALSVHAHRVSNVGNNIRNATIDDTIQKMYYSPP 427

  Fly   426 VLQALRAVRFIAQHIKDADKDNEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAIICQSPSLYDTR 490
            |::|...:.|||:.:|..|:|::|.||||:|:|||||.||.:|:::|..||:.|:.::|:|||||
Worm   428 VVKAFENICFIAELLKKKDRDDKIDEDWKYVAMVLDRLFLLIFSIACFVGTVIILLRAPTLYDTR 492

  Fly   491 SPIDRQLSEIPLRKN 505
            .|||.|.....|..|
Worm   493 QPIDLQYRPANLSAN 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	240/500 (48%)
nAChRbeta2	NP_524483.1	LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	117/232 (50%)
unc-38	NP_491472.1	Neur_chan_LBD	27..257	CDD:280998	115/229 (50%)
		LIC	29..483	CDD:273305	233/475 (49%)
		Neur_chan_memb	264..481	CDD:280999	111/238 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	524	1.000	Inparanoid score	I677
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45250
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	1	1.000	-	-		FOG0000583
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101158
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X294
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.840