DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRbeta2 and Chrnb3

DIOPT Version :9

Sequence 1:	NP_524483.1	Gene:	nAChRbeta2 / 42920	FlyBaseID:	FBgn0004118	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_598281.1	Gene:	Chrnb3 / 171131	RGDID:	621544	Length:	464	Species:	Rattus norvegicus

Alignment Length:	493	Identity:	215/493 - (43%)
Similarity:	310/493 - (62%)	Gaps:	54/493 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LCVFLLV--PLANSTAPISFEANPDTKRLYDD-----LLSNYNRLIRPVVNNTETLTVWLGLKLS 64
            |.|||::  .|:.|...::..|...:...::|     |...|.:.:|||:|:::.:.|:.|||:|
  Rat     5 LRVFLVLSATLSGSWVTLTATAGLSSVAEHEDALLRHLFQGYQKWVRPVLNSSDIIKVYFGLKIS 69

  Fly    65 QLIEVNLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVT 129
            ||::|:.|||:||||:|:||.|.|.||||:||||||:..:.||||.:|:|||||:.|.||.:|.:
  Rat    70 QLVDVDEKNQLMTTNVWLKQEWTDQKLRWNPEEYGGINSIKVPSESLWLPDIVLFENADGRFEGS 134

  Fly   130 LMTKATLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSN 194
            |||||.:|.:|.|.|.|||.|||||.|:|.:||:|.|.|.||||||||:|..|||         .
  Rat   135 LMTKAIVKSSGTVSWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDL---------I 190

  Fly   195 LVQVGIDLTEFYLSVEWDILEVPATK---NEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPC 256
            |:...:|..:|:.:.||:||.....|   .|.:|.   .||  :|:...:||..||||:.||:||
  Rat   191 LINENVDRKDFFDNGEWEILNAKGMKGNRREGFYS---YPF--VTYSFVLRRLPLFYTLFLIIPC 250

  Fly   257 VALTFLTVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSL 321
            :.|:||||||||||||.|||::|..|:|||||||.|::.||||.:|..:||:|:||||.||.|:|
  Rat   251 LGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTL 315

  Fly   322 SVWTTVCVLNIHFRSPST-HNMSPLVRKLFLHFMPKLMMMR--RTQYTLPDYDDSTPSNGYTNEI 383
            |:..||.|:|:|.||.|| |.|:|.|::|||..:|:.:.|:  ..:::.||        |..::.
  Rat   316 SIIVTVFVINVHHRSSSTYHPMAPWVKRLFLQRLPRWLCMKDPMDRFSFPD--------GKESDT 372

  Fly   384 DVRDSISDFPSEFKDSQDGAYDNGMQNSVDSDNVIPRNLTPEVLQALRAVRFIAQHIKDADKDNE 448
            .||..:|.     |..|..|.|.            .|.|...:.:|..::|:|::|:|.....::
  Rat   373 AVRGKVSG-----KRKQTPASDG------------ERVLVAFLEKASESIRYISRHVKKEHFISQ 420

  Fly   449 IVEDWKFVSMVLDRFFLWLFTLSCVFGTLAIICQSPSL 486
            :|:|||||:.||||.|||||.::.|.|::.|..  |:|
  Rat   421 VVQDWKFVAQVLDRIFLWLFLIASVLGSILIFI--PAL 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	211/482 (44%)
nAChRbeta2	NP_524483.1	LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	102/225 (45%)
Chrnb3	NP_598281.1	LIC	29..455	CDD:273305	206/466 (44%)
		Neur_chan_LBD	35..239	CDD:280998	102/217 (47%)
		Neur_chan_memb	246..452	CDD:280999	99/230 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	253	1.000	Domainoid score	I1995
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45250
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm12327
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.830