DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRbeta2 and HTR3C

DIOPT Version :9

Sequence 1:	NP_524483.1	Gene:	nAChRbeta2 / 42920	FlyBaseID:	FBgn0004118	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_570126.2	Gene:	HTR3C / 170572	HGNCID:	24003	Length:	447	Species:	Homo sapiens

Alignment Length:	343	Identity:	88/343 - (25%)
Similarity:	162/343 - (47%)	Gaps:	42/343 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 PISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQR 85
            |..|:|..|.|            ..||..|.:....|.:...||.::.|:.:.|::|:.||:...
Human    42 PAVFQAVFDRK------------AFRPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLV 94

  Fly    86 WFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKATLKYTGEVFWEPPAIY 150
            |.:..:.|:|:|..|:.:|.|.:|::|:|||.:..:.|.:...:.:| |.:...|.:.::.|...
Human    95 WDNPFINWNPKECVGINKLTVLAENLWLPDIFIVESMDVDQTPSGLT-AYISSEGRIKYDKPMRV 158

  Fly   151 KSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGID-----LTEFYLSV- 209
            .|.|.:::.|||:|:|.|...|.|:.|.   ||           .:.:|:|     :|:....|
Human   159 TSICNLDIFYFPFDQQNCTFTFSSFLYT---VD-----------SMLLGMDKEVWEITDTSRKVI 209

  Fly   210 ----EWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLP 270
                ||::|.:.....:....:.|  :..|.|.:.:||:...|.:||:||...|..:..|.||||
Human   210 QTQGEWELLGINKATPKMSMGNNL--YDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLP 272

  Fly   271 SDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLN-IHF 334
            ::|..:....|::|:...||.|::.:::|.:  ..||:..|....:.|:.:|:..||.:.. :|.
Human   273 AESENRAPFKITLLLGYNVFLLMMNDLLPAS--GTPLISVYFALCLSLMVVSLLETVFITYLLHV 335

  Fly   335 RSPSTHNMSPLVRKLFLH 352
            .:.....|...:..|.||
Human   336 ATTQPPPMPRWLHSLLLH 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	88/343 (26%)
nAChRbeta2	NP_524483.1	LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	55/227 (24%)
HTR3C	NP_570126.2	Neur_chan_LBD	43..445	CDD:332142	87/342 (25%)
HTR3C	NP_570126.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	380..405
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810