Protein Alignment nAChRbeta2 and LOC1275447

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: XP_061509055.1
• Gene: LOC1275447 / 1275447
• VectorBaseID: AGAMI1_001711
• Length: 551
• Species: Anopheles gambiae
• Alignment Length: 528
• Identity: 194/528 - (36%)
• Similarity: 307/528 - (58%)
• Gaps: 56/528 - (10%)

  Fly     1 MWHWSLLCVFLLVPLANSTAPISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQ 65
            ::.|    :.:|:.:|||:  |...|..:.|||..|||.:||.|.|||||.::.|.:..||.|.|
Mosquito    35 IYKW----IIVLMLIANSS--ILCMAGYNEKRLLHDLLDSYNILERPVVNESDPLQLSFGLTLMQ 93

  Fly    66 LIEVNLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTL 130
            :|:|:.|||::.||:|:|..|.|..|||:..|||||..|.:|...||.||:::||:.|..::.|.
Mosquito    94 IIDVDEKNQLLVTNIWLKLEWNDMNLRWNTSEYGGVRDLRIPPHRIWKPDVLMYNSADEGFDGTY 158

  Fly   131 MTKATLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNL 195
            .|...::..|...:.||.|:||:|::::.:||:|:|.|.||||||||:|.|:||:..|:..|
Mosquito   159 PTNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQLQDEAGG--- 220

  Fly   196 VQVGIDLTEFYLSVEWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALT 260
                 |::.|..:.|||:|.||..:||.||....||:.||||.:.:||:||:|..|||||||.:.
Mosquito   221 -----DVSSFVTNGEWDLLGVPGKRNEIYYNCCPEPYIDITFAIIIRRRTLYYFFNLIVPCVLIA 280

  Fly   261 FLTVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWT 325
            .:.:|.|.||.|||||::|.::||:|||||..::||.:|.||.||||||.|....|.:|:.||.:
Mosquito   281 SMALLGFTLPPDSGEKLSLGVTILLSLTVFLNMVAETMPATSDAVPLLGTYFNCIMFMVASSVVS 345

  Fly   326 TVCVLNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRR------TQYTLPDYDDSTPSNGYTNEID 384
            |:.:||.|.|:..||.||..||.:||:::|.::.|.|      .:|......||:....:..:::
Mosquito   346 TILILNYHHRNADTHEMSDWVRVIFLYWLPCILRMSRPGRDLSMEYPPTPTSDSSERKAHIQDVE 410

  Fly   385 VRD--------SISDFPSEFKDS-----------QDGAYDNGMQNSVDSD------NVIPRNLTP 424
            :::        ::.|...:|:.:           .:..|...:.:|.|..      |.:|..:.|
Mosquito   411 LKERSSKSLLANVLDIDDDFRHNCRPLTPGGTLPHNPTYFRTVYSSDDGSIGPIGTNRMPDAIAP 475

  Fly   425 -----------EVLQALRAVRFIAQHIKDADKDNEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLA 478
                       |:...|:.:|||...|:..|::::|.:||||.:||:||..|.:||...:..|:|
Mosquito   476 PHTCFTSSADYELALILKEIRFITDQIRKEDEESDIAKDWKFAAMVVDRLCLIIFTFFTIVATIA 540

  Fly   479 IICQSPSL 486
            ::..:|.:
Mosquito   541 VLFSAPHI 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	191/511 (37%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	96/217 (44%)
		Cys-loop	154..168	CDD:349832	5/13 (38%)
LOC1275447	XP_061509055.1	None