Protein Alignment nAChRbeta2 and nAChRalpha4

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: XP_061501006.1
• Gene: nAChRalpha4 / 1272129
• VectorBaseID: AGAMI1_012397
• Length: 557
• Species: Anopheles gambiae
• Alignment Length: 522
• Identity: 290/522 - (55%)
• Similarity: 369/522 - (70%)
• Gaps: 52/522 - (9%)

  Fly    27 NPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYKL 91
            |||.||||||||||||:|:|||||.::.|.|.:.|||||||:||||||:|||||||:|.|:||||
Mosquito    29 NPDAKRLYDDLLSNYNKLVRPVVNTSDVLRVCIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKL 93

  Fly    92 RWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKATLKYTGEVFWEPPAIYKSSCEM 156
            ||:|:|||||:.|:|||:|||.||||||||.|||:||||.||||:...|.|.|:||||||||||:
Mosquito    94 RWEPKEYGGVQMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATIYSEGLVEWKPPAIYKSSCEI 158

  Fly   157 NVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDLTEFYLSVEWDILEVPATKN 221
            :|||||:|||.|.:|||||||:|.:|||:|:|:..|||:|.||:||:|||:|||||||||||.:|
Mosquito   159 DVEYFPFDEQTCVLKFGSWTYDGFKVDLRHMDEKSGSNIVDVGVDLSEFYMSVEWDILEVPAVRN 223

  Fly   222 EEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDSGEKVTLCISILVS 286
            |::|....||:.||||.:||||||||||||:|:||:.::|||||.|||||||||||||.||||:|
Mosquito   224 EKFYTCCDEPYLDITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPSDSGEKVTLSISILIS 288

  Fly   287 LTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIHFRSPSTHNMSPLVRKLFL 351
            |.|||||:.||||||||.||||||||:|.|||||:|:..||.|||:|||||.||.|:|.|:..|:
Mosquito   289 LHVFFLLVVEIIPPTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQTHRMAPWVKTFFI 353

  Fly   352 HFMPKLMMMRRTQYT---------------LPDYDDSTPSN--GYTNEIDVRDSISDFPSEFKDS 399
            .|:|:.:.|:|..|.               .|.|..:|.:.  .:||....::.:|  ||..  |
Mosquito   354 DFLPRFLFMKRPPYIENHRKLLSKDLHACFYPYYSTTTLNRIARFTNRAPSKEDLS--PSSL--S 414

  Fly   400 QDGAYDNGMQ----------------NSVDSDNVIPRNL---------------TPEVLQALRAV 433
            ..|.:....|                .|..:|..:|..:               :.||.::...|
Mosquito   415 GTGPFGGSCQIHGPIQLPHSESEELSMSTAADTAVPSGIKSPAFKQPAFSHSVCSTEVHRSCFCV 479

  Fly   434 RFIAQHIKDADKDNEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAIICQSPSLYDTRSPIDRQLS 498
            ||||:|.|..:...::.||||:|:|||||.|||:|||:.:.||..||.|:|:|||.|.|||:...
Mosquito   480 RFIAEHTKMLEDSTKVKEDWKYVAMVLDRLFLWIFTLAVLAGTAGIILQAPTLYDDRIPIDKTFD 544

  Fly   499 EI 500
            |:
Mosquito   545 EL 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	278/499 (56%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	153/217 (71%)
		Cys-loop	154..168	CDD:349832	10/13 (77%)
nAChRalpha4	XP_061501006.1	None