Protein Alignment nAChRbeta2 and LOC1268935

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: XP_307512.4
• Gene: LOC1268935 / 1268935
• VectorBaseID: AGAMI1_005560
• Length: 424
• Species: Anopheles gambiae
• Alignment Length: 508
• Identity: 104/508 - (20%)
• Similarity: 179/508 - (35%)
• Gaps: 159/508 - (31%)

  Fly    10 FLLVPLA-----NSTAPISFEANPDTKR------LYDDLLSN-YNRLIRPVVN-----NTETLTV 57
            |:.:||.     :|.:.|    |.|.||      :...|..| |:..|||..:     |..|..|
Mosquito     7 FIYLPLLVAFLFDSASSI----NCDKKRDNVQYTIKQHLFCNGYDPKIRPAKSEFDSINITTYAV 67

  Fly    58 WLGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNW 122
            .....:|:.      ..||:..:....||.|..|.|:..::..:..|.:.::.||.|.   :.|.
Mosquito    68 LYSFDISEY------RSVMSFQVNYYMRWQDSSLAWNASDWSNITTLNINNDEIWSPQ---FENI 123

  Fly   123 DGNYE-----VTLMTKATLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQV 182
            :.:||     ..|.....|:..|.|...|.....:.|..:...:|::..:|.|    |..|.
Mosquito   124 NSDYEGQPSVSCLNPDCLLRVNGYVSCSPVCRISAKCSSDYSRWPFNTLVCRM----WFTNR--- 181

  Fly   183 DLKHLDQIPGSNLVQVGIDLTEFYL-------SVEWDILEVPATKNEEYYPD-TLEPFSDITFKL 239
            |.:.:|::   |.:.|   :|  ||       :.:|.:..:.:.|.:...|. |.....::.|.|
Mosquito   182 DKELVDEV---NFLPV---IT--YLPSNRHLPTTKWCVTSISSNKTQLSIPGATSRTVEELEFNL 238

  Fly   240 TMRRKTLFYTVNLIV-----PCVALTFLTVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIP 299
            .       ::.:||:     |..||:.|.:.|..|.|...||:.:   .|:.:...|.||.::..
Mosquito   239 E-------HSPHLIIAIIYLPAFALSMLNIFVCLLDSRVKEKIVI---PLICMIFHFQLLQQMSN 293

  Fly   300 PTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRRTQ 364
            ||. .:|.:..:::.:|||..|..                  :|.|:.: :||.:
Mosquito   294 PTP-EIPGVVLFIIASMILTFLLF------------------VSTLINR-WLHGL---------- 328

  Fly   365 YTLPDYDDSTPSNGYTNEIDVRDSISDFPSEFKDSQDGAYDNGMQN---SVDSDNVIPRNLTPEV 426
                   .|||.|     |.:|            |......|.:.|   .||..:|..:..|
Mosquito   329 -------QSTPPN-----IVIR------------SMRAILSNRLMNWILKVDYLSVGQKTCT--- 366

  Fly   427 LQALRAVRFIAQHIKDADKDNEIVEDWKFVSMVLDRF-----------FLWLF 468
                           ..:.|..:..||.....::|||           |.|::
Mosquito   367 ---------------IINNDERLTLDWVMFVKLVDRFILAAYVIIYLLFFWIY 404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	104/508 (20%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	51/242 (21%)
		Cys-loop	154..168	CDD:349832	2/13 (15%)
LOC1268935	XP_307512.4	None