Protein Alignment nAChRbeta2 and LOC116410385

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: XP_031756604.1
• Gene: LOC116410385 / 116410385
• XenbaseID: XB-GENE-29096091
• Length: 456
• Species: Xenopus tropicalis
• Alignment Length: 455
• Identity: 110/455 - (24%)
• Similarity: 211/455 - (46%)
• Gaps: 64/455 - (14%)

  Fly    45 IRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSE 109
            :||.:..|:...|.|.|.|..:|:::::.|::||.:|....|.:..:.||...|.|:|::.|...
 Frog    42 VRPTMVWTDRTNVTLDLALYSIIDLDMQQQIITTYIWFSMSWKNDFVNWDSNTYCGIEKVVVSDT 106

  Fly   110 HIWVPDIVLYNNWDGNYEVTLMTKATLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGS 174
            .:|.||:.:|...|.:.:...:....:.|.|.|....|.....||.|....||:|||.|.:.|||
 Frog   107 LVWRPDLYIYEMVDDDDKSPKINYLKIYYNGIVTNSKPLRIAGSCSMQNFKFPFDEQNCSLTFGS 171

  Fly   175 WTYNGAQVDLKHLDQIPGSNLVQVGIDLTE-----FYLSVEWDILEVPATKNEEYYPDTLEPFSD 234
            :.||..:|.:     :..||..||    ||     |....:|.:|.:....|    |.....|:.
 Frog   172 YVYNDFEVYM-----MAASNSSQV----TENSKDIFRTKGDWILLNIIVRNN----PLPSGNFNR 223

  Fly   235 ITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIP 299
            :|:::.::|..:.|..|||:|...|..|.:...::....| ::|..::|::..:|..|:|:.::
 Frog   224 VTYEIHIKRNPIIYVFNLILPACFLVILDIASMFMEGTEG-RLTFKVTIVLGFSVLLLILSGML- 286

  Fly   300 PTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRRTQ 364
            |.|...|:||.:....||::.||:...:|.:::..:. :|.::...::|..:.:: ..::...|:
 Frog   287 PNSDTPPMLGIFFSVCMIMMVLSIGGCICTVSMRTKC-ATASVPLWIKKWIIGYL-ACVLCYETK 349

  Fly   365 YTLPDY------------DDSTPSNGYTNEIDVRDSISDFPSEFKDSQDGAYDNGMQNSVDSDNV 417
            : :.::            .|..|    ||:|:|.:.                   .:|..|.|
 Frog   350 F-IKEHLVKVVSRIHTCEHDQKP----TNKIEVEEK-------------------RRNLADED-- 388

  Fly   418 IPRNLTPEVL-QALRAVRFIAQHIK-DADKDNEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAII 480
             |...:.::| :.|..::.|...|. ...||:..:| :...:||||||||.::.::.:..|..:|
 Frog   389 -PITTSVQILNKMLVGIKKIHHEIAVSKHKDDSSLE-FYIAAMVLDRFFLIIYLITVIITTSIMI 451

  Fly   481  480
             Frog   452  451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	109/452 (24%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	57/206 (28%)
		Cys-loop	154..168	CDD:349832	7/13 (54%)
LOC116410385	XP_031756604.1	LGIC_ECD	23..233	CDD:475126	56/203 (28%)
		LGIC_TM	235..>319	CDD:476813	23/85 (27%)
		TM1 helix	239..259	CDD:349850	6/19 (32%)
		TM2 helix	266..287	CDD:349850	5/21 (24%)
		TM3 helix	297..319	CDD:349850	5/21 (24%)