Protein Alignment nAChRbeta2 and Chrne

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: XP_006532069.1
• Gene: Chrne / 11448
• MGIID: 87894
• Length: 494
• Species: Mus musculus
• Alignment Length: 501
• Identity: 163/501 - (32%)
• Similarity: 262/501 - (52%)
• Gaps: 53/501 - (10%)

  Fly     5 SLLCVFLLVPLANSTAPISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEV 69
            :||...||:.|...:     :...:...||..|..||:...|||....:|:|:.|.:.|:.||.:
Mouse     4 ALLGALLLLTLFGRS-----QGKNEELSLYHHLFDNYDPECRPVRRPEDTVTITLKVTLTNLISL 63

  Fly    70 NLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKA 134
            |.|.:.:||::|:...|.||:|.:..:::.||..|.|||||:|:|:|||.||.||.:.|...:..
Mouse    64 NEKEETLTTSVWIGIDWHDYRLNYSKDDFAGVGILRVPSEHVWLPEIVLENNIDGQFGVAYDSNV 128

  Fly   135 TLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVG 199
            .:...|.|.|.|||||:|:|.:.|.|||:|.|.|.:.|.|.|||..:|:........|:.:.::.
Mouse   129 LVYEGGYVSWLPPAIYRSTCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFIFAVDDDGNTINKID 193

  Fly   200 IDLTEFYLSVEWDILEVPATKNEEYYPDTLEPF----------SDITFKLTMRRKTLFYTVNLIV 254
            ||...|..:.||.|         :|.|..:..:          :|:.:.|.:|||.|||.:|:||
Mouse   194 IDTAAFTENGEWAI---------DYCPGMIRRYEGGSTEGPGETDVIYTLIIRRKPLFYVINIIV 249

  Fly   255 PCVALTFLTVLVFYLPSDS-GEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMIL 318
            |||.::.|.:|.::||:.: |:|.|:.|::|::.|||..|:|:.||.|||:|||||:||:|.|::
Mouse   250 PCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRYLIFVMVV 314

  Fly   319 VSLSVWTTVCVLNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRRTQYTLPDYDDSTPSNG----- 378
            .:|.|...|.|||:..|:|:||..||.:|::.|..:|:|:     ..:.|..|..|.|..
Mouse   315 ATLIVMNCVIVLNVSLRTPTTHATSPRLRQILLELLPRLL-----GSSPPPEDPRTASPARRASS 374

  Fly   379 -----YTNEIDVRDSISDFPSEFKDSQDGAYDNGMQNSVDSDNVIPRNL---TPEVLQALRAVRF 435
                 ...|:.::...|:...|.:..:.|.:         :...:.:||   .||:...:.||.|
Mouse   375 VGILLRAEELILKKPRSELVFEGQRHRHGTW---------TAAALCQNLGAAAPEIRCCVDAVNF 430

  Fly   436 IAQHIKDADKDNEIVEDWKFVSMVLDRFFLW-LFTLSCVFGTLAII 480
            :|:..:|.:...|.:.||..:...||....| ...|..|..||..:
Mouse   431 VAESTRDQEATGEELSDWVRMGKALDNVCFWAALVLFSVGSTLIFL 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	161/494 (33%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	78/227 (34%)
		Cys-loop	154..168	CDD:349832	7/13 (54%)
Chrne	XP_006532069.1	LGIC_ECD_nAChR_E	49..239	CDD:349831	67/198 (34%)
		Cys-loop	148..162	CDD:349831	7/13 (54%)
		Neur_chan_memb	247..475	CDD:460753	76/241 (32%)