DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRbeta2 and Chrnd

DIOPT Version :9

Sequence 1:	NP_524483.1	Gene:	nAChRbeta2 / 42920	FlyBaseID:	FBgn0004118	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_067611.2	Gene:	Chrnd / 11447	MGIID:	87893	Length:	520	Species:	Mus musculus

Alignment Length:	498	Identity:	180/498 - (36%)
Similarity:	275/498 - (55%)	Gaps:	29/498 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLCVFLLVPLANSTAPISFEANPDTKRLYDDLLS--NYNRLIRPVVNNTETLTVWLGLKLSQLIE 68
            :|.:.||..|.....|.|:..| :.:||...|.:  .|::.:|||....:.:.|.|.|.||.||.
Mouse     5 VLTLGLLAALVVCALPGSWGLN-EEQRLIQHLFNEKGYDKDLRPVARKEDKVDVALSLTLSNLIS 68

  Fly    69 VNLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTK 133
            :....:.:|||:|:...|.|.:|:||..::|.:..|.:|.:.:|:|:|||.||.||:::::....
Mouse    69 LKEVEETLTTNVWIDHAWVDSRLQWDANDFGNITVLRLPPDMVWLPEIVLENNNDGSFQISYACN 133

  Fly   134 ATLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSN---- 194
            ..:..:|.|.|.||||::|||.::|.|||:|.|.|.:||.|..|...::.|. |.|...:|
Mouse   134 VLVYDSGYVTWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLS-LKQEEENNRSYP 197

  Fly   195 LVQVGIDLTEFYLSVEWDILEVPATKN-EEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVA 258
            :..:.||...|..:.||:|:...|..| :...|.......|:||.|.:|||.|||.:|::||||.
Mouse   198 IEWIIIDPEGFTENGEWEIVHRAAKLNVDPSVPMDSTNHQDVTFYLIIRRKPLFYIINILVPCVL 262

  Fly   259 LTFLTVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSV 323
            ::|:..||||||.|.|||.::.||:|::.:||.||:::.:|.||:|:||:||:|||.|:||::.|
Mouse   263 ISFMINLVFYLPGDCGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLVGKFLLFGMVLVTMVV 327

  Fly   324 WTTVCVLNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRRTQYTLPDYDDSTP--------SNGY- 379
            ...|.|||||||:||||.:|..|:|.||..:|||:.|.|     |..:|..|        |.||
Mouse   328 VICVIVLNIHFRTPSTHVLSEGVKKFFLETLPKLLHMSR-----PAEEDPGPRALIRRSSSLGYI 387

  Fly   380 --TNEIDVRDSISDFPSEFKDSQDG---AYDNGMQNSVDSDNVIPRNLTPEVLQALRAVRFIAQH 439
              ..|.....|.||...|.:..:.|   ......:....|:.| .:.|..|:..|:....||..|
Mouse   388 CKAEEYFSLKSRSDLMFEKQSERHGLARRLTTARRPPASSEQV-QQELFNEMKPAVDGANFIVNH 451

  Fly   440 IKDADKDNEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAIICQ 482
            ::|.:..||..::|..|:..:||..|::.|...|.||..|..|
Mouse   452 MRDQNSYNEEKDNWNQVARTVDRLCLFVVTPVMVVGTAWIFLQ 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	177/490 (36%)
nAChRbeta2	NP_524483.1	LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	76/224 (34%)
Chrnd	NP_067611.2	LIC	1..479	CDD:273305	174/481 (36%)
		Neur_chan_LBD	28..249	CDD:280998	75/221 (34%)
		Neur_chan_memb	256..492	CDD:280999	91/241 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810