Protein Alignment nAChRbeta2 and Chrnb1

DIOPT Version :9

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_033731.3
• Gene: Chrnb1 / 11443
• MGIID: 87890
• Length: 501
• Species: Mus musculus
• Alignment Length: 499
• Identity: 182/499 - (36%)
• Similarity: 285/499 - (57%)
• Gaps: 45/499 - (9%)

  Fly     6 LLCVFLLVPLANSTAPISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVN 70
            ||...|..|||........|.     :|...|.|||:..:||.....:.:.|.:||.|:|||.:|
Mouse     8 LLLGVLGTPLAPGARGSEAEG-----QLIKKLFSNYDSSVRPAREVGDRVGVSIGLTLAQLISLN 67

  Fly    71 LKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKAT 135
            .|::.|:|.:::...|.||:|.|||.|:.|::.|.:.:|.:|:||:||.||.|||::|.|.....
Mouse    68 EKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDINVV 132

  Fly   136 LKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGI 200
            :.:.|.|.|:||.:|:|||.:.|.|||:|.|.|.|.|.|::|:.::|.||......|....:|.|
Mouse   133 VSFEGSVRWQPPGLYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLKTGLDPEGEERQEVYI 197

  Fly   201 DLTEFYLSVEWDILEVPAT----------KNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVP 255
            ....|..:.:|:|:..|:.          ..|.::       .::.|.|.:|||.|||.||:|.|
Mouse   198 HEGTFIENGQWEIIHKPSRLIQLPGDQRGGKEGHH-------EEVIFYLIIRRKPLFYLVNVIAP 255

  Fly   256 CVALTFLTVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVS 320
            |:.:|.|.:.|||||.|:|||:.|.|..|::||||.||||:.:|.||||||::.|||:|||:||:
Mouse   256 CILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLAVPIIIKYLMFTMVLVT 320

  Fly   321 LSVWTTVCVLNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRR---TQYTLPD-YDDSTPSNGY-- 379
            .||..:|.|||:|.|||.||.|...||::|:|.:|..:.::|   .:..||: :...:|.:|:
Mouse   321 FSVILSVVVLNLHHRSPHTHQMPFWVRQIFIHKLPPYLGLKRPKPERDQLPEPHHSLSPRSGWGR 385

  Fly   380 -TNEIDVRDSISD--FP--SEFKDSQDG----AYDNGMQNSVDSDNVIPRNLTPEVLQALRAVRF 435
             |:|..:|...||  ||  :.|:.....    .:.:|...:|        .|..|:.:.:.::.:
Mouse   386 GTDEYFIRKPPSDFLFPKLNRFQPESSAPDLRRFIDGPTRAV--------GLPQELREVISSISY 442

  Fly   436 IAQHIKDADKDNEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAI 479
            :|:.:::.:..:.:.|||:||:||:||.|||.|.:....|||.|
Mouse   443 MARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIVFTSVGTLVI 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	179/494 (36%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	77/227 (34%)
Chrnb1	NP_033731.3	LIC	24..488	CDD:273305	176/483 (36%)
		Neur_chan_LBD	27..245	CDD:280998	77/229 (34%)
		Neur_chan_memb	252..487	CDD:280999	93/243 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	362..382		4/19 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810