DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRbeta2 and Chrna7

DIOPT Version :9

Sequence 1:	NP_524483.1	Gene:	nAChRbeta2 / 42920	FlyBaseID:	FBgn0004118	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_031416.3	Gene:	Chrna7 / 11441	MGIID:	99779	Length:	502	Species:	Mus musculus

Alignment Length:	490	Identity:	177/490 - (36%)
Similarity:	274/490 - (55%)	Gaps:	47/490 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 KRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYKLRWDP 95
            :|||.:|:.|||.|.|||.|:::.|||:..|.|.|:::|:.||||:|||:|::..|.|:.|:|:.
Mouse    27 RRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNM 91

  Fly    96 EEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKATLKYTGEVFWEPPAIYKSSCEMNVEY 160
            .||.||:.:..|...||.|||:|||:.|..::.|..|...:..:|...:.||.|:||||.::|.:
Mouse    92 SEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRW 156

  Fly   161 FPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDLTEFYLSVEWDILEVPATKNEEYY 225
            ||:|.|.|.:|||||:|.|..:||:..:           .|::.:..:.|||::.:|..:||::|
Mouse   157 FPFDVQQCKLKFGSWSYGGWSLDLQMQE-----------ADISSYIPNGEWDLMGIPGKRNEKFY 210

  Fly   226 PDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDSGEKVTLCISILVSLTVF 290
            ....||:.|:|:.:||||:||:|.:||::|||.::.|.:|||.||:|||||::|.|::|:|||||
Mouse   211 ECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVF 275

  Fly   291 FLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIHFRSPSTHNMSPLVRKLFLHFMP 355
            .||:|||:|.||.:|||:.:|...|||:|.|||..||.||..|...|....|....|.:.|::..
Mouse   276 MLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCA 340

  Fly   356 KLMMMRRTQYTLPDYDDSTP------------------------SNGYTNEIDVRDSISDFPSEF 396
            ..:.|:|     |..|...|                        |||....|..|.......:..
Mouse   341 WFLRMKR-----PGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPT 400

  Fly   397 KDSQDGAYDNGMQNSVDSDNVI-----PRNLTPEVLQALRAVRFIAQHIKDADKDNEIVEDWKFV 456
            .||  |.....:..|...|..:     |.:..|::.:.|..||:||...:..|:...|..:|||.
Mouse   401 PDS--GVVCGRLACSPTHDEHLMHGTHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFA 463

  Fly   457 SMVLDRFFLWLFTLSCVFGTLAIICQSPSLYDTRS 491
            :.|:||..|..|::..:..|:.|:..:|:..:..|
Mouse   464 ACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVS 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	174/476 (37%)
nAChRbeta2	NP_524483.1	LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	87/215 (40%)
Chrna7	NP_031416.3	LIC	4..490	CDD:273305	175/480 (36%)
		Neur_chan_LBD	26..230	CDD:280998	86/213 (40%)
		Neur_chan_memb	237..486	CDD:280999	84/255 (33%)
		Essential for TMEM35A/NACHO-mediated proper subunit assembly and trafficking to cell membrane. /evidence=ECO:0000269\|PubMed:32783947	260..267		3/6 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910