DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRbeta2 and Chrna6

DIOPT Version :9

Sequence 1:	NP_524483.1	Gene:	nAChRbeta2 / 42920	FlyBaseID:	FBgn0004118	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_067344.2	Gene:	Chrna6 / 11440	MGIID:	106213	Length:	494	Species:	Mus musculus

Alignment Length:	516	Identity:	222/516 - (43%)
Similarity:	320/516 - (62%)	Gaps:	67/516 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWHWSLLCVFLLVPLANSTAPISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQ 65
            :|    ||.||.: ...||...|.|      :|:..|.::|||.||||.|.::.:||...|.::|
Mouse    16 LW----LCGFLAL-FKGSTGCESEE------QLFHRLFAHYNRFIRPVENVSDPVTVHFELAITQ 69

  Fly    66 LIEVNLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTL 130
            |..|:..||:|.||||::..|.||:|||||.||.|:|.|.||:::||.||||||||..|:::|..
Mouse    70 LANVDEVNQIMETNLWLRHIWKDYRLRWDPTEYDGIETLRVPADNIWKPDIVLYNNAVGDFQVEG 134

  Fly   131 MTKATLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNL 195
            .|||.|||.|.:.|.||||:||||.|::.:||:|.|.|.:|||||||:.|::||    .|.||.
Mouse   135 KTKALLKYDGVITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDL----LIIGSK- 194

  Fly   196 VQVGIDLTEFYLSVEWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALT 260
                :|:.:|:.:.||:|::....|::..|....|.::|||:...:||..:|||:|||:||:.::
Mouse   195 ----VDMNDFWENSEWEIVDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFIS 255

  Fly   261 FLTVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWT 325
            ||||||||||||.|||||||||:|:|||||.|::.|.||.|||.:||:|:|||||||.|:||:..
Mouse   256 FLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLVGEYLLFTMIFVTLSIVV 320

  Fly   326 TVCVLNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRRTQYTLPDYDDSTPSNG------------ 378
            ||.|||||:|:|:||.|...|:.:||...|.::|||:..       |.|...|
Mouse   321 TVFVLNIHYRTPATHTMPKWVKTIFLQAFPSILMMRKPL-------DKTKEAGGVKDPKSHTKRP 378

  Fly   379 ----YTNEIDVR--------DSISDF-PSEFKDSQDGA--YDNGMQNSVDSDNVIPRNLTPEVLQ 428
                :|:..:.:        ...||. |.:.:.||..|  .....::|.|.::||
Mouse   379 AKVKFTHRGESKLLKECHHCQKSSDIAPGKRRSSQQPARWVAENSEHSSDVEDVI---------- 433

  Fly   429 ALRAVRFIAQHIKDADKDNEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAIICQSPSLYDT 489
              .:|:|||:::|..::.||:.:|||:::||:||.|||:|.:.|||||:.:..| |.|.:|
Mouse   434 --ESVQFIAENMKSHNETNEVEDDWKYMAMVVDRVFLWVFIIVCVFGTVGLFLQ-PLLGNT 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	215/496 (43%)
nAChRbeta2	NP_524483.1	LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	98/217 (45%)
Chrna6	NP_067344.2	LIC	15..484	CDD:273305	218/506 (43%)
		Neur_chan_LBD	34..240	CDD:280998	99/220 (45%)
		Neur_chan_memb	247..483	CDD:280999	107/254 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	399..423		6/23 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	253	1.000	Domainoid score	I2060
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	476	1.000	Inparanoid score	I1470
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45250
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	1	1.000	-	-		FOG0000583
OrthoInspector	1	1.000	-	-		mtm8871
orthoMCL	1	0.900	-	-		OOG6_101158
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2381
SonicParanoid	1	1.000	-	-		X294
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910