Protein Alignment nAChRbeta2 and CHRND

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_000742.1
• Gene: CHRND / 1144
• HGNCID: 1965
• Length: 517
• Species: Homo sapiens
• Alignment Length: 485
• Identity: 178/485 - (36%)
• Similarity: 276/485 - (56%)
• Gaps: 38/485 - (7%)

  Fly    31 KRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYKLRWDP 95
            :.|:.:  ..||:.:|||.:..|::.|.|.|.||.||.:....:.:|||:|::..|.|.:|:|:.
Human    30 RHLFQE--KGYNKELRPVAHKEESVDVALALTLSNLISLKEVEETLTTNVWIEHGWTDNRLKWNA 92

  Fly    96 EEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKATLKYTGEVFWEPPAIYKSSCEMNVEY 160
            ||:|.:..|.:|.:.:|:|:|||.||.||:::::......:.:.|.|:|.||||::|||.::|.|
Human    93 EEFGNISVLRLPPDMVWLPEIVLENNNDGSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTY 157

  Fly   161 FPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSN----LVQVGIDLTEFYLSVEWDILEVPATKN 221
            ||:|.|.|.:||.|..|...::.|. |.|....|    :..:.||...|..:.||:|:..||..|
Human   158 FPFDWQNCSLKFSSLKYTAKEITLS-LKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVN 221

  Fly   222 EEYYPDTLEPF-----SDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDSGEKVTLCI 281
                .|...|.     .||||.|.:|||.|||.:|::||||.::|:..||||||:|||||.::.|
Human   222 ----VDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAI 282

  Fly   282 SILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIHFRSPSTHNMSPLV 346
            |:|::.:||.||:::.:|.||:|:||:||:|||.|:||::.|...|.|||||||:||||.:|..|
Human   283 SVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPSTHVLSEGV 347

  Fly   347 RKLFLHFMPKLMMMRRTQYTLPDYDDSTP--------SNGYTNEID---VRDSISDFPSEFKDSQ 400
            :||||..:|:|:.|.|     |..|..:|        |.||.::.:   :..|.||...|.:..:
Human   348 KKLFLETLPELLHMSR-----PAEDGPSPGALVRRSSSLGYISKAEEYFLLKSRSDLMFEKQSER 407

  Fly   401 DG---AYDNGMQNSVDSDNVIPRNLTPEVLQALRAVRFIAQHIKDADKDNEIVEDWKFVSMVLDR 462
            .|   ......:....|:.. .:.|..|:..|:....||..|::|.:..||..:.|..|:..:||
Human   408 HGLARRLTTARRPPASSEQA-QQELFNELKPAVDGANFIVNHMRDQNNYNEEKDSWNRVARTVDR 471

  Fly   463 FFLWLFTLSCVFGTLAIICQSPSLYDTRSP 492
            ..|::.|...|.||..|..|  .:|:...|
Human   472 LCLFVVTPVMVVGTAWIFLQ--GVYNQPPP 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	174/470 (37%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	80/224 (36%)
		Cys-loop	154..168	CDD:349832	7/13 (54%)
CHRND	NP_000742.1	LGIC_ECD_nAChR_D	26..246	CDD:349829	79/222 (36%)
		Cys-loop	151..165	CDD:349829	7/13 (54%)
		Neur_chan_memb	253..489	CDD:460753	90/241 (37%)