Protein Alignment nAChRbeta2 and Chrna4

DIOPT Version :9

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_056545.3
• Gene: Chrna4 / 11438
• MGIID: 87888
• Length: 629
• Species: Mus musculus
• Alignment Length: 619
• Identity: 239/619 - (38%)
• Similarity: 321/619 - (51%)
• Gaps: 156/619 - (25%)

  Fly     6 LLCVFLLVPLANSTAPISFEANPDTK-----RLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQ 65
            ||.:.||:.|.....|.|  ::.:|:     ||...|.|.||:..|||.|.::.:.|..||.::|
Mouse    12 LLLLPLLLLLGTGLLPAS--SHIETRAHAEERLLKRLFSGYNKWSRPVANISDVVLVRFGLSIAQ 74

  Fly    66 LIEVNLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTL 130
            ||:|:.|||:||||:||||.|.||||||||.:|..|..:.:|||.||.||||||||.||::.||.
Mouse    75 LIDVDEKNQMMTTNVWVKQEWHDYKLRWDPGDYENVTSIRIPSELIWRPDIVLYNNADGDFAVTH 139

  Fly   131 MTKATLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNL 195
            :|||.|.|.|.|.|.|||||||||.::|.:||:|:|.|.||||||||:.|::||..:..
Mouse   140 LTKAHLFYDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVSMHS------ 198

  Fly   196 VQVGIDLTEFYLSVEWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALT 260
               .:|..:|:.|.||.|::...|.|...|....|.:.|||:...:||..||||:|||:||:.::
Mouse   199 ---RVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFIIRRLPLFYTINLIIPCLLIS 260

  Fly   261 FLTVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWT 325
            .||||||||||:.|||||||||:|:|||||.||:.||||.|||.:||:|:|||||||.|:||:..
Mouse   261 CLTVLVFYLPSECGEKVTLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVI 325

  Fly   326 TVCVLNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRR---------------------------- 362
            ||.|||:|.|||.||.|...||::||..:|:|:.|:|
Mouse   326 TVFVLNVHHRSPRTHTMPAWVRRVFLDIVPRLLFMKRPSVVKDNCRRLIESMHKMANAPRFWPEP 390

  Fly   363 ------------------------------TQYT-------LPDYDDS-------TPSNGYTNE- 382
                                          ||.|       :||...|       .||.|..:.
Mouse   391 ESEPGILGDICNQGLSPAPTFCNRMDTAVETQPTCRSPSHKVPDLKTSEVEKASPCPSPGSCHPP 455

  Fly   383 --------IDVRD-SISDFPS----------------EFKDSQDGAYD------NGMQNSVD--- 413
                    |..|. |:...||                ::..|||||..      .|...|:.
Mouse   456 NSSGAPVLIKARSLSVQHVPSSQEAAEGSIRCRSRSIQYCVSQDGAASLTESKPTGSPASLKTRP 520

  Fly   414 -----SDNVIPRN----------------------------LTPEVLQALRAVRFIAQHIKDADK 445
                 ||...|..                            |:|.:.:|:..|::||.|:|..|.
Mouse   521 SQLPVSDQTSPCKCTCKEPSPVSPITVLKAGGTKAPPQHLPLSPALTRAVEGVQYIADHLKAEDT 585

  Fly   446 DNEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAI 479
            |..:.||||:|:||:||.|||:|.:.|:.||:.:
Mouse   586 DFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGL 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	237/614 (39%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	106/222 (48%)
Chrna4	NP_056545.3	Neur_chan_LBD	39..245	CDD:280998	105/214 (49%)
		Neur_chan_memb	252..620	CDD:280999	121/368 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	420..459		9/38 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	503..529		4/25 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	253	1.000	Domainoid score	I2060
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	476	1.000	Inparanoid score	I1470
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8871
orthoMCL	1	0.900	-	-		OOG6_101158
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X294
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.760