DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRbeta2 and Chrna1

DIOPT Version :9

Sequence 1:	NP_524483.1	Gene:	nAChRbeta2 / 42920	FlyBaseID:	FBgn0004118	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_031415.2	Gene:	Chrna1 / 11435	MGIID:	87885	Length:	457	Species:	Mus musculus

Alignment Length:	480	Identity:	206/480 - (42%)
Similarity:	293/480 - (61%)	Gaps:	43/480 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLCVFLLVPLANSTAPISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVN 70
            |..|.||:.|.::...:..|   ...||...|..:|:.::|||.::.|.:.|.:||:|.|||.|:
Mouse     3 LSTVLLLLGLCSAGLVLGSE---HETRLVAKLFEDYSSVVRPVEDHREIVQVTVGLQLIQLINVD 64

  Fly    71 LKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKAT 135
            ..||::|||:.:||:|.||.|:|:|::||||:::::|||.||.||:|||||.||::.:...||..
Mouse    65 EVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDVVLYNNADGDFAIVKFTKVL 129

  Fly   136 LKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGI 200
            |.|||.:.|.||||:||.||:.|.:||:|||.|.||.|:|||:|:.|.:......|
Mouse   130 LDYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQP--------- 185

  Fly   201 DLTEFYLSVEWDILEVPATKNEEYY---PDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFL 262
            ||:.|..|.||.|.|....|:..:|   |.|  |:.|||:...|:|..|::.||:|:||:..:||
Mouse   186 DLSNFMESGEWVIKEARGWKHWVFYSCCPTT--PYLDITYHFVMQRLPLYFIVNVIIPCLLFSFL 248

  Fly   263 TVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTV 327
            |.||||||:|||||:||.||:|:|||||.|::.|:||.||.||||:|||:||||:.|..|:..||
Mouse   249 TSLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITV 313

  Fly   328 CVLNIHFRSPSTHNMSPLVRKLFLHFMPKLMM---MRRTQYTLPDYDDSTPSNGYTNEIDVRDSI 389
            .|:|.|.||||||.|...|||:|:..:|.:|.   |:|..      .|......:|.:||:.| |
Mouse   314 IVINTHHRSPSTHIMPEWVRKVFIDTIPNIMFFSTMKRPS------RDKQEKRIFTEDIDISD-I 371

  Fly   390 SDFPSEFKDSQDGAYDNGMQNSVDSDNVIPRNLTPEVLQALRAVRFIAQHIKDADKDNEIVEDWK 454
            |..|        |....|..:        |....|||..|:..|::||:.:|...:.|...|:||
Mouse   372 SGKP--------GPPPMGFHS--------PLIKHPEVKSAIEGVKYIAETMKSDQESNNAAEEWK 420

  Fly   455 FVSMVLDRFFLWLFTLSCVFGTLAI 479
            :|:||:|...|.:|.|.|:.||||:
Mouse   421 YVAMVMDHILLGVFMLVCLIGTLAV 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	204/475 (43%)
nAChRbeta2	NP_524483.1	LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	96/220 (44%)
Chrna1	NP_031415.2	Neur_chan_LBD	24..231	CDD:308532	96/217 (44%)
Chrna1	NP_031415.2	Neur_chan_memb	238..446	CDD:308533	101/231 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920