Protein Alignment nAChRbeta2 and Chrna1

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_031415.2
• Gene: Chrna1 / 11435
• MGIID: 87885
• Length: 457
• Species: Mus musculus
• Alignment Length: 480
• Identity: 206/480 - (42%)
• Similarity: 293/480 - (61%)
• Gaps: 43/480 - (8%)

  Fly     6 LLCVFLLVPLANSTAPISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVN 70
            |..|.||:.|.::...:..|   ...||...|..:|:.::|||.::.|.:.|.:||:|.|||.|:
Mouse     3 LSTVLLLLGLCSAGLVLGSE---HETRLVAKLFEDYSSVVRPVEDHREIVQVTVGLQLIQLINVD 64

  Fly    71 LKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKAT 135
            ..||::|||:.:||:|.||.|:|:|::||||:::::|||.||.||:|||||.||::.:...||..
Mouse    65 EVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDVVLYNNADGDFAIVKFTKVL 129

  Fly   136 LKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGI 200
            |.|||.:.|.||||:||.||:.|.:||:|||.|.||.|:|||:|:.|.:......|
Mouse   130 LDYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQP--------- 185

  Fly   201 DLTEFYLSVEWDILEVPATKNEEYY---PDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFL 262
            ||:.|..|.||.|.|....|:..:|   |.|  |:.|||:...|:|..|::.||:|:||:..:||
Mouse   186 DLSNFMESGEWVIKEARGWKHWVFYSCCPTT--PYLDITYHFVMQRLPLYFIVNVIIPCLLFSFL 248

  Fly   263 TVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTV 327
            |.||||||:|||||:||.||:|:|||||.|::.|:||.||.||||:|||:||||:.|..|:..||
Mouse   249 TSLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITV 313

  Fly   328 CVLNIHFRSPSTHNMSPLVRKLFLHFMPKLMM---MRRTQYTLPDYDDSTPSNGYTNEIDVRDSI 389
            .|:|.|.||||||.|...|||:|:..:|.:|.   |:|..      .|......:|.:||:.| |
Mouse   314 IVINTHHRSPSTHIMPEWVRKVFIDTIPNIMFFSTMKRPS------RDKQEKRIFTEDIDISD-I 371

  Fly   390 SDFPSEFKDSQDGAYDNGMQNSVDSDNVIPRNLTPEVLQALRAVRFIAQHIKDADKDNEIVEDWK 454
            |..|        |....|..:        |....|||..|:..|::||:.:|...:.|...|:||
Mouse   372 SGKP--------GPPPMGFHS--------PLIKHPEVKSAIEGVKYIAETMKSDQESNNAAEEWK 420

  Fly   455 FVSMVLDRFFLWLFTLSCVFGTLAI 479
            :|:||:|...|.:|.|.|:.||||:
Mouse   421 YVAMVMDHILLGVFMLVCLIGTLAV 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	204/475 (43%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	96/220 (44%)
		Cys-loop	154..168	CDD:349832	8/13 (62%)
Chrna1	NP_031415.2	LIC	21..447	CDD:455710	201/462 (44%)
		LGIC_ECD_nAChR_A1	22..231	CDD:349815	97/222 (44%)
		Cys-loop	148..162	CDD:349815	8/13 (62%)