Protein Alignment nAChRbeta2 and CHRNB3

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_000740.1
• Gene: CHRNB3 / 1142
• HGNCID: 1963
• Length: 458
• Species: Homo sapiens
• Alignment Length: 484
• Identity: 209/484 - (43%)
• Similarity: 306/484 - (63%)
• Gaps: 43/484 - (8%)

  Fly     6 LLCVFLLVPLANSTAPISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVN 70
            |:.:.|.:|.:.:|...|...|.|.  |...|...|.:.:|||:::.:|:.|:.|||:|||::|:
Human     7 LVLIVLGIPSSATTGFNSIAENEDA--LLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQLVDVD 69

  Fly    71 LKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKAT 135
            .|||:||||:|:||.|.|:||||:|::|||:..:.||||.:|:|||||:.|.||.:|.:||||..
Human    70 EKNQLMTTNVWLKQEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADGRFEGSLMTKVI 134

  Fly   136 LKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGI 200
            :|..|.|.|.|||.|||||.|:|.:||:|.|.|.||||||||:|..|||         .|:...:
Human   135 VKSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDL---------ILINENV 190

  Fly   201 DLTEFYLSVEWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVL 265
            |..:|:.:.||:||.....|...  .|.:..:..||:...:||..||||:.||:||:.|:|||||
Human   191 DRKDFFDNGEWEILNAKGMKGNR--RDGVYSYPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTVL 253

  Fly   266 VFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVL 330
            |||||||.|||::|..|:|||||||.|::.||||.:|..:||:|:||||.||.|:||:..||.|:
Human   254 VFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVI 318

  Fly   331 NIHFRSPST-HNMSPLVRKLFLHFMPKLMMMRR--TQYTLPDYDDSTPSNGYTNEIDVRDSISDF 392
            |:|.||.|| |.|:|.|::|||..:|||:.|:.  .:|:.|:.::|.|.        |:..:.:.
Human   319 NVHHRSSSTYHPMAPWVKRLFLQKLPKLLCMKDHVDRYSSPEKEESQPV--------VKGKVLEK 375

  Fly   393 PSEFKDSQDGAYDNGMQNSVDSDNVIPRNLTPEVLQALRAVRFIAQHIKDADKDNEIVEDWKFVS 457
            ..: |...||                .:.|...:.:|..::|:|::|:|.....:::|:|||||:
Human   376 KKQ-KQLSDG----------------EKVLVAFLEKAADSIRYISRHVKKEHFISQVVQDWKFVA 423

  Fly   458 MVLDRFFLWLFTLSCVFGTLAIICQSPSL 486
            .||||.|||||.:..|.|::.|.  :|:|
Human   424 QVLDRIFLWLFLIVSVTGSVLIF--TPAL 450

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	205/472 (43%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	98/217 (45%)
		Cys-loop	154..168	CDD:349832	7/13 (54%)
CHRNB3	NP_000740.1	LIC	23..449	CDD:455710	203/465 (44%)