Protein Alignment nAChRbeta2 and CHRNB1

DIOPT Version :9

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_000738.2
• Gene: CHRNB1 / 1140
• HGNCID: 1961
• Length: 501
• Species: Homo sapiens
• Alignment Length: 500
• Identity: 183/500 - (36%)
• Similarity: 288/500 - (57%)
• Gaps: 50/500 - (10%)

  Fly    11 LLVPLANSTAPISFEANPDTK------RLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEV 69
            ||:.|....||::    |..:      ||.:.|.|.|:..:||.....:.:.|.:||.|:|||.:
Human     6 LLMLLGALGAPLA----PGVRGSEAEGRLREKLFSGYDSSVRPAREVGDRVRVSVGLILAQLISL 66

  Fly    70 NLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKA 134
            |.|::.|:|.:::...|.||:|.|||.|:.|::.|.:.:|.:|:||:||.||.|||::|.|....
Human    67 NEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDISV 131

  Fly   135 TLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVG 199
            .:...|.|.|:||.||:|||.:.|.|||:|.|.|.|.|.|::|:.::|.|:......|....::.
Human   132 VVSSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQTGLGPDGQGHQEIH 196

  Fly   200 IDLTEFYLSVEWDILEVPATKNEEYYPDTLEPFSD-----------ITFKLTMRRKTLFYTVNLI 253
            |....|..:.:|:|:..|:.        .::|..|           :.|.|.:|||.|||.||:|
Human   197 IHEGTFIENGQWEIIHKPSR--------LIQPPGDPRGGREGQRQEVIFYLIIRRKPLFYLVNVI 253

  Fly   254 VPCVALTFLTVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMIL 318
            .||:.:|.|.:.|||||.|:|||:.|.|..|::||||.||||:.:|.|||:||::.|||:|||:|
Human   254 APCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTMVL 318

  Fly   319 VSLSVWTTVCVLNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRRTQYTLPDYD-------DSTPS 376
            |:.||..:|.|||:|.|||.||.|...||::|:|.:|..:.::|.:   |:.|       .|:|.
Human   319 VTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLPLYLRLKRPK---PERDLMPEPPHCSSPG 380

  Fly   377 NGY---TNEIDVRDSISDF----PSEFKDSQDGAYDNGMQNSVDSDNVIPRNLTPEVLQALRAVR 434
            :|:   |:|..:|...|||    |:.|:......   .::..:|..|.... |.||:.:.:.::.
Human   381 SGWGRGTDEYFIRKPPSDFLFPKPNRFQPELSAP---DLRRFIDGPNRAVA-LLPELREVVSSIS 441

  Fly   435 FIAQHIKDADKDNEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAI 479
            :||:.:::.:..:.:.|||:||:||:||.|||.|.:....|||.|
Human   442 YIARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIIFTSVGTLVI 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	182/498 (37%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	77/234 (33%)
CHRNB1	NP_000738.2	Neur_chan_LBD	27..245	CDD:308532	76/225 (34%)
		Neur_chan_memb	252..487	CDD:308533	94/241 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810