Protein Alignment nAChRbeta2 and CHRNA5

DIOPT Version :9

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_000736.2
• Gene: CHRNA5 / 1138
• HGNCID: 1959
• Length: 468
• Species: Homo sapiens
• Alignment Length: 473
• Identity: 198/473 - (41%)
• Similarity: 292/473 - (61%)
• Gaps: 66/473 - (13%)

  Fly    21 PISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQR 85
            |.|...:.|:  |..||..:|.|.:|||.:..:.:.:..||.:|||::|:.|||:||||:|:||.
Human    40 PSSIAKHEDS--LLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQE 102

  Fly    86 WFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKATLKYTGEVFWEPPAIY 150
            |.|.||||:|::|||::.:.|||:.:|.|||||::|.||.:|.| .||..::|.|.|.|.|||.|
Human   103 WIDVKLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRFEGT-STKTVIRYNGTVTWTPPANY 166

  Fly   151 KSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDLTEFYLSVEWDILE 215
            ||||.::|.:||:|.|.|.||||||||:|:|||:...||         .:|..:|:.:.||:|:.
Human   167 KSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQ---------DVDKRDFFDNGEWEIVS 222

  Fly   216 VPATKNEE-----YYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDSGE 275
            ...:|...     :||       .:|:...::|..||||:.||:||:.|:|||||||||||:.||
Human   223 ATGSKGNRTDSCCWYP-------YVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGE 280

  Fly   276 KVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIHFRSPSTH 340
            |:.||.|:|||||||.|::.||||.:|..:||:|:||:||||.|:||:..||..:|||.||.|||
Human   281 KICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTH 345

  Fly   341 N-MSPLVRKLFLHFMPKLMMMRRTQYTLPDYDDSTPSNGYTNEIDVRDSISDFPSEFKDSQDGAY 404
            | |:|||||:|||.:|||:.|                         |..:..:.::.::::.|:.
Human   346 NAMAPLVRKIFLHTLPKLLCM-------------------------RSHVDRYFTQKEETESGSG 385

  Fly   405 DNGMQNSVDSDNVIPRNLTPEVLQALRAVRFIAQHIKDADKDNEIVEDWKFVSMVLDRFFLWLFT 469
            ....:|::::              ||.::|:|.:||...:...|:||||||::.||||.|||.|.
Human   386 PKSSRNTLEA--------------ALDSIRYITRHIMKENDVREVVEDWKFIAQVLDRMFLWTFL 436

  Fly   470 LSCVFGTLAIICQSPSLY 487
            ...:.|:|.:..  |.:|
Human   437 FVSIVGSLGLFV--PVIY 452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	196/463 (42%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	93/222 (42%)
CHRNA5	NP_000736.2	LIC	39..449	CDD:273305	196/468 (42%)
		Neur_chan_LBD	47..250	CDD:280998	93/221 (42%)
		Neur_chan_memb	257..447	CDD:280999	97/228 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	251	1.000	Domainoid score	I2107
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45250
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.830