Protein Alignment nAChRbeta2 and CHRNA3

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_000734.2
• Gene: CHRNA3 / 1136
• HGNCID: 1957
• Length: 505
• Species: Homo sapiens
• Alignment Length: 498
• Identity: 222/498 - (44%)
• Similarity: 326/498 - (65%)
• Gaps: 40/498 - (8%)

  Fly     6 LLCVFLLVPLANSTAPISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVN 70
            ||.:..|:|:|.::     ||.   .||::.|..:||.:||||.|.::.:.:...:.:|||::|:
Human    19 LLLLLSLLPVARAS-----EAE---HRLFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVD 75

  Fly    71 LKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKAT 135
            ..||:|.||||:||.|.||||:|:|.:|||.|.:.||::.||.||||||||..|:::|...|||.
Human    76 EVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKAL 140

  Fly   136 LKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGI 200
            |||||||.|.||||:||||:::|.|||:|.|.|.||||||:|:.|::||.         |:...:
Human   141 LKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLV---------LIGSSM 196

  Fly   201 DLTEFYLSVEWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVL 265
            :|.:::.|.||.|::.|..|::..|....|.:.|||:.|.:||..||||:|||:||:.::|||||
Human   197 NLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVL 261

  Fly   266 VFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVL 330
            |||||||.|||||||||:|:|||||.|::.|.||.|||.:||:|:|||||||.|:||:..||.||
Human   262 VFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVL 326

  Fly   331 NIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRRTQYTLPDYDDSTPSNGYTNEIDVRDSISDFPS- 394
            |:|:|:|:||.|...|:.:||:.:|::|.|  |:.|..:.:...|...|..|:...:..|...|
Human   327 NVHYRTPTTHTMPSWVKTVFLNLLPRVMFM--TRPTSNEGNAQKPRPLYGAELSNLNCFSRAESK 389

  Fly   395 ---EFKDSQDGA-------------YDNGMQNSVDSDNVIP----RNLTPEVLQALRAVRFIAQH 439
               |....|||.             :...:..|..|::|..    ..|:||:.:|:::|::||::
Human   390 GCKEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAEN 454

  Fly   440 IKDADKDNEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAIICQ 482
            :|..::..||.:|||:|:||:||.|||:|||.|:.||..:..|
Human   455 MKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFLQ 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	219/490 (45%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	100/217 (46%)
		Cys-loop	154..168	CDD:349832	7/13 (54%)
CHRNA3	NP_000734.2	LIC	30..496	CDD:455710	216/484 (45%)
		LGIC_ECD_nAChR_A3	35..241	CDD:349817	100/217 (46%)
		Cys-loop	159..173	CDD:349817	7/13 (54%)