DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRbeta2 and CHRNA3

DIOPT Version :9

Sequence 1:NP_524483.1 Gene:nAChRbeta2 / 42920 FlyBaseID:FBgn0004118 Length:519 Species:Drosophila melanogaster
Sequence 2:NP_000734.2 Gene:CHRNA3 / 1136 HGNCID:1957 Length:505 Species:Homo sapiens


Alignment Length:498 Identity:222/498 - (44%)
Similarity:326/498 - (65%) Gaps:40/498 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 LLCVFLLVPLANSTAPISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVN 70
            ||.:..|:|:|.::     ||.   .||::.|..:||.:||||.|.::.:.:...:.:|||::|:
Human    19 LLLLLSLLPVARAS-----EAE---HRLFERLFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVD 75

  Fly    71 LKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKAT 135
            ..||:|.||||:||.|.||||:|:|.:|||.|.:.||::.||.||||||||..|:::|...|||.
Human    76 EVNQIMETNLWLKQIWNDYKLKWNPSDYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKAL 140

  Fly   136 LKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGI 200
            |||||||.|.||||:||||:::|.|||:|.|.|.||||||:|:.|::||.         |:...:
Human   141 LKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLV---------LIGSSM 196

  Fly   201 DLTEFYLSVEWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVL 265
            :|.:::.|.||.|::.|..|::..|....|.:.|||:.|.:||..||||:|||:||:.::|||||
Human   197 NLKDYWESGEWAIIKAPGYKHDIKYNCCEEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVL 261

  Fly   266 VFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVL 330
            |||||||.|||||||||:|:|||||.|::.|.||.|||.:||:|:|||||||.|:||:..||.||
Human   262 VFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVL 326

  Fly   331 NIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRRTQYTLPDYDDSTPSNGYTNEIDVRDSISDFPS- 394
            |:|:|:|:||.|...|:.:||:.:|::|.|  |:.|..:.:...|...|..|:...:..|...| 
Human   327 NVHYRTPTTHTMPSWVKTVFLNLLPRVMFM--TRPTSNEGNAQKPRPLYGAELSNLNCFSRAESK 389

  Fly   395 ---EFKDSQDGA-------------YDNGMQNSVDSDNVIP----RNLTPEVLQALRAVRFIAQH 439
               |....|||.             :...:..|..|::|..    ..|:||:.:|:::|::||::
Human   390 GCKEGYPCQDGMCGYCHHRRIKISNFSANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAEN 454

  Fly   440 IKDADKDNEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAIICQ 482
            :|..::..||.:|||:|:||:||.|||:|||.|:.||..:..|
Human   455 MKAQNEAKEIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFLQ 497

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRbeta2NP_524483.1 LIC 9..479 CDD:273305 219/490 (45%)
LGIC_ECD_nAChR_proto_alpha-like 29..247 CDD:349832 100/217 (46%)
CHRNA3NP_000734.2 Neur_chan_LBD 30..496 CDD:332142 216/484 (45%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 251 1.000 Domainoid score I2107
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 485 1.000 Inparanoid score I1448
Isobase 1 0.950 - 0 Normalized mean entropy S3292
OMA 1 1.010 - - QHG45250
OrthoDB 1 1.010 - - D188416at33208
OrthoFinder 1 1.000 - - FOG0000583
OrthoInspector 1 1.000 - - mtm8639
orthoMCL 1 0.900 - - OOG6_101158
Panther 1 1.100 - - LDO PTHR18945
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2381
SonicParanoid 1 1.000 - - X294
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1413.860

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