DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRbeta2 and CHRNA2

DIOPT Version :9

Sequence 1:	NP_524483.1	Gene:	nAChRbeta2 / 42920	FlyBaseID:	FBgn0004118	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_000733.2	Gene:	CHRNA2 / 1135	HGNCID:	1956	Length:	529	Species:	Homo sapiens

Alignment Length:	472	Identity:	217/472 - (45%)
Similarity:	295/472 - (62%)	Gaps:	37/472 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 RLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYKLRWDPE 96
            ||:..|...|||..|||.|.::.:.|..||.::|||:|:.|||:||||:|:||.|.||||||:|.
Human    61 RLFKHLFRGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRWNPT 125

  Fly    97 EYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKATLKYTGEVFWEPPAIYKSSCEMNVEYF 161
            ::|.:..|.||||.||:||||||||.||.:.||.||||.|..||.|.|.|||||||||.::|.:|
Human   126 DFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSSCSIDVTFF 190

  Fly   162 PYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDLTEFYLSVEWDILEVPATKNEEYYP 226
            |:|:|.|.||||||||:.|::||:.::|.         :||.:::.|.||.|:....|.|.:.|.
Human   191 PFDQQNCKMKFGSWTYDKAKIDLEQMEQT---------VDLKDYWESGEWAIVNATGTYNSKKYD 246

  Fly   227 DTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDSGEKVTLCISILVSLTVFF 291
            ...|.:.|:|:...:||..||||:|||:||:.::.|||||||||||.|||:|||||:|:|||||.
Human   247 CCAEIYPDVTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTVFL 311

  Fly   292 LLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIHFRSPSTHNMSPLVRKLFLHFMPK 356
            ||:.||||.|||.:||:|:|||||||.|:||:..||.|||:|.||||||.|...||...|..:|:
Human   312 LLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHTMPHWVRGALLGCVPR 376

  Fly   357 LMMMRRTQYTL-----------PDYD------DSTPSNGYTNEID-------VRDSISDFPSEFK 397
            .::|.|....:           |.|.      |:........|.|       |..|:....|. .
Human   377 WLLMNRPPPPVELCHPLRLKLSPSYHWLESNVDAEEREVVVEEEDRWACAGHVAPSVGTLCSH-G 440

  Fly   398 DSQDGAYDNGMQNSVDSDNVIPRNLTPEVLQALRAVRFIAQHIKDADKDNEIVEDWKFVSMVLDR 462
            ....||.....:..:....::   |:|.:.:||..|.:||.|::..|.|:.:.||||:|:||:||
Human   441 HLHSGASGPKAEALLQEGELL---LSPHMQKALEGVHYIADHLRSEDADSSVKEDWKYVAMVIDR 502

  Fly   463 FFLWLFTLSCVFGTLAI 479
            .|||||.:.|..||:.:
Human   503 IFLWLFIIVCFLGTIGL 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	217/470 (46%)
nAChRbeta2	NP_524483.1	LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	105/214 (49%)
CHRNA2	NP_000733.2	LIC	57..522	CDD:273305	217/472 (46%)
		Neur_chan_LBD	59..265	CDD:280998	105/212 (50%)
		Neur_chan_memb	272..520	CDD:280999	107/252 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	251	1.000	Domainoid score	I2107
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	485	1.000	Inparanoid score	I1448
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45250
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	1	1.000	-	-		FOG0000583
OrthoInspector	1	1.000	-	-		mtm8639
orthoMCL	1	0.900	-	-		OOG6_101158
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2381
SonicParanoid	1	1.000	-	-		X294
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.810