Protein Alignment nAChRbeta2 and CHRNA1

DIOPT Version :9

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: XP_016858745.1
• Gene: CHRNA1 / 1134
• HGNCID: 1955
• Length: 489
• Species: Homo sapiens
• Alignment Length: 479
• Identity: 198/479 - (41%)
• Similarity: 283/479 - (59%)
• Gaps: 65/479 - (13%)

  Fly    32 RLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQ------------ 84
            ||...|..:|:.::|||.::.:.:.|.:||:|.|||.|:..||::|||:.:||
Human    33 RLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQGDMVDLPRPSCV 97

  Fly    85 -------------RWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKATL 136
                         :|.||.|:|:|::||||:::::|||.||.||:|||||.||::.:...||..|
Human    98 TLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLL 162

  Fly   137 KYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGID 201
            :|||.:.|.||||:||.||:.|.:||:|||.|.||.|:|||:|:.|.:......|         |
Human   163 QYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQP---------D 218

  Fly   202 LTEFYLSVEWDILEVPATKNEEYY---PDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLT 263
            |:.|..|.||.|.|....|:...|   |||  |:.|||:...|:|..|::.||:|:||:..:|||
Human   219 LSNFMESGEWVIKESRGWKHSVTYSCCPDT--PYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLT 281

  Fly   264 VLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVC 328
            .||||||:|||||:||.||:|:|||||.|::.|:||.||.||||:|||:||||:.|..|:..||.
Human   282 GLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVI 346

  Fly   329 VLNIHFRSPSTHNMSPLVRKLFLHFMPKLMM---MRRTQYTLPDYDDSTPSNGYTNEIDVRDSIS 390
            |:|.|.||||||.|...|||:|:..:|.:|.   |:|......|      ...:|.:||:.| ||
Human   347 VINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQD------KKIFTEDIDISD-IS 404

  Fly   391 DFPSEFKDSQDGAYDNGMQNSVDSDNVIPRNLTPEVLQALRAVRFIAQHIKDADKDNEIVEDWKF 455
            ..|        |....|..:        |....|||..|:..:::||:.:|...:.|....:||:
Human   405 GKP--------GPPPMGFHS--------PLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKY 453

  Fly   456 VSMVLDRFFLWLFTLSCVFGTLAI 479
            |:||:|...|.:|.|.|:.||||:
Human   454 VAMVMDHILLGVFMLVCIIGTLAV 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	197/477 (41%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	96/242 (40%)
CHRNA1	XP_016858745.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920