Protein Alignment nAChRbeta2 and CHRNA1

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: XP_016858745.1
• Gene: CHRNA1 / 1134
• HGNCID: 1955
• Length: 489
• Species: Homo sapiens
• Alignment Length: 479
• Identity: 198/479 - (41%)
• Similarity: 283/479 - (59%)
• Gaps: 65/479 - (13%)

  Fly    32 RLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQ------------ 84
            ||...|..:|:.::|||.::.:.:.|.:||:|.|||.|:..||::|||:.:||
Human    33 RLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQGDMVDLPRPSCV 97

  Fly    85 -------------RWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKATL 136
                         :|.||.|:|:|::||||:::::|||.||.||:|||||.||::.:...||..|
Human    98 TLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLL 162

  Fly   137 KYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGID 201
            :|||.:.|.||||:||.||:.|.:||:|||.|.||.|:|||:|:.|.:......|         |
Human   163 QYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQP---------D 218

  Fly   202 LTEFYLSVEWDILEVPATKNEEYY---PDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLT 263
            |:.|..|.||.|.|....|:...|   |||  |:.|||:...|:|..|::.||:|:||:..:|||
Human   219 LSNFMESGEWVIKESRGWKHSVTYSCCPDT--PYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLT 281

  Fly   264 VLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVC 328
            .||||||:|||||:||.||:|:|||||.|::.|:||.||.||||:|||:||||:.|..|:..||.
Human   282 GLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVI 346

  Fly   329 VLNIHFRSPSTHNMSPLVRKLFLHFMPKLMM---MRRTQYTLPDYDDSTPSNGYTNEIDVRDSIS 390
            |:|.|.||||||.|...|||:|:..:|.:|.   |:|......|      ...:|.:||:.| ||
Human   347 VINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQD------KKIFTEDIDISD-IS 404

  Fly   391 DFPSEFKDSQDGAYDNGMQNSVDSDNVIPRNLTPEVLQALRAVRFIAQHIKDADKDNEIVEDWKF 455
            ..|        |....|..:        |....|||..|:..:::||:.:|...:.|....:||:
Human   405 GKP--------GPPPMGFHS--------PLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKY 453

  Fly   456 VSMVLDRFFLWLFTLSCVFGTLAI 479
            |:||:|...|.:|.|.|:.||||:
Human   454 VAMVMDHILLGVFMLVCIIGTLAV 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	197/477 (41%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	96/242 (40%)
		Cys-loop	154..168	CDD:349832	8/13 (62%)
CHRNA1	XP_016858745.1	LGIC_ECD_nAChR_A1	29..263	CDD:349815	96/240 (40%)
		Cys-loop	180..194	CDD:349815	8/13 (62%)
		Neur_chan_memb	270..478	CDD:460753	99/231 (43%)