DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRbeta2 and Chrna2

DIOPT Version :9

Sequence 1:NP_524483.1 Gene:nAChRbeta2 / 42920 FlyBaseID:FBgn0004118 Length:519 Species:Drosophila melanogaster
Sequence 2:NP_659052.1 Gene:Chrna2 / 110902 MGIID:87886 Length:512 Species:Mus musculus


Alignment Length:513 Identity:232/513 - (45%)
Similarity:319/513 - (62%) Gaps:56/513 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 W-HWSLLCVFLLVP--LANSTAPISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKL 63
            | |..|.|: ||:|  ||...:....|     .||:..|...|||..|||.|.::.:.|..||.:
Mouse    11 WIHLYLWCL-LLMPAVLAQQGSHTHAE-----DRLFKHLFGGYNRWARPVPNTSDVVIVRFGLSI 69

  Fly    64 SQLIEVNLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEV 128
            :|||:|:.|||:||||:|:||.|.||||||||.|:|.:..|.||||.||:||||||||.||.:.|
Mouse    70 AQLIDVDEKNQMMTTNVWLKQEWNDYKLRWDPAEFGNITSLRVPSEMIWIPDIVLYNNADGEFAV 134

  Fly   129 TLMTKATLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGS 193
            |.||||.|.:||.|.|.|||||||||.::|.:||:|:|.|.||||||||:.|::||:.:::.   
Mouse   135 THMTKAHLFFTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMERT--- 196

  Fly   194 NLVQVGIDLTEFYLSVEWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVA 258
                  :||.:::.|.||.|:....|.|.:.|....|.:.|:|:...:||..||||:|||:||:.
Mouse   197 ------VDLKDYWESGEWAIINATGTYNSKKYDCCAEIYPDVTYYFVIRRLPLFYTINLIIPCLL 255

  Fly   259 LTFLTVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSV 323
            ::.||||||||||:.|||:|||||:|:|||||.||:.||||.|||.:||:|:|||||||.|:||:
Mouse   256 ISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSI 320

  Fly   324 WTTVCVLNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRRTQYTLPDYD-DSTP----SNGY---- 379
            ..||.|||:|.||||||||...||...|..:|:.:||.|   .||..: ..:|    |..|    
Mouse   321 VITVFVLNVHHRSPSTHNMPNWVRVALLGRVPRWLMMNR---PLPPMELHGSPGLKLSPTYHWLE 382

  Fly   380 TN-EIDVRDSISDFPSEFKDSQ----DGAYDNGM------------------QNSVDSDNVIPRN 421
            || :.:.|:...:...|.:|..    .|..|:.|                  :....:..::   
Mouse   383 TNMDAEEREETEEEEEEEEDENICMCAGLPDSSMGVLYGHGSLHLRAMGPEAKTPSQASEIL--- 444

  Fly   422 LTPEVLQALRAVRFIAQHIKDADKDNEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAI 479
            |:|::.:||..|.:||.|::..|.|:.:.||||:|:||:||.|||||.:.|..||:.:
Mouse   445 LSPQIQKALEGVHYIADHLRSEDADSSVKEDWKYVAMVVDRIFLWLFIIVCFLGTIGL 502

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRbeta2NP_524483.1 LIC 9..479 CDD:273305 228/503 (45%)
LGIC_ECD_nAChR_proto_alpha-like 29..247 CDD:349832 106/217 (49%)
Chrna2NP_659052.1 LIC 15..505 CDD:273305 230/509 (45%)
LGIC_ECD_nAChR_A2 36..242 CDD:349816 107/219 (49%)
Cys-loop 160..174 CDD:349816 6/13 (46%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 253 1.000 Domainoid score I2060
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 476 1.000 Inparanoid score I1470
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45250
OrthoDB 1 1.010 - - D188416at33208
OrthoFinder 1 1.000 - - FOG0000583
OrthoInspector 1 1.000 - - mtm8871
orthoMCL 1 0.900 - - OOG6_101158
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2381
SonicParanoid 1 1.000 - - X294
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1312.810

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