DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRbeta2 and Chrna5

DIOPT Version :9

Sequence 1:	NP_524483.1	Gene:	nAChRbeta2 / 42920	FlyBaseID:	FBgn0004118	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001360830.1	Gene:	Chrna5 / 110835	MGIID:	87889	Length:	467	Species:	Mus musculus

Alignment Length:	463	Identity:	196/463 - (42%)
Similarity:	285/463 - (61%)	Gaps:	69/463 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYKLRWDPEE 97
            |:.||..:|.:.:|||.:.::.:.:..||.:|||::|:.|||:||||:|:||.|.|.||||:|::
Mouse    50 LFRDLFEDYEKWVRPVEHLSDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDD 114

  Fly    98 YGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKATLKYTGEVFWEPPAIYKSSCEMNVEYFP 162
            |||::.:.|||:.:|:|||||::|.||.:| ...||..::|.|.|.|..||.|||||.::|.:||
Mouse   115 YGGIKIIRVPSDSLWIPDIVLFDNADGRFE-GASTKTVVRYNGTVTWTQPANYKSSCTIDVTFFP 178

  Fly   163 YDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDLTEFYLSVEWDILEVPATKNEE---- 223
            :|.|.|.||||||||:|:|||:...||         .:|.|:|:.:.||:|:....:|...
Mouse   179 FDLQNCSMKFGSWTYDGSQVDIILEDQ---------DVDRTDFFDNGEWEIMSAMGSKGNRTDSC 234

  Fly   224 -YYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDSGEKVTLCISILVSL 287
             :||       .||:...::|..||||:.||:||:.|:||||:||||||:.|||::||.|:||||
Mouse   235 CWYP-------CITYSFVIKRLPLFYTLFLIIPCIGLSFLTVVVFYLPSNEGEKISLCTSVLVSL 292

  Fly   288 TVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIHFRSPSTHN-MSPLVRKLFL 351
            |||.|::.||||.:|..:||:|:||:||||.|:||:..||..:|||.||.|||| |:|.|||:||
Mouse   293 TVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPWVRKIFL 357

  Fly   352 HFMPKLMMMRRTQYTLPDYDDSTPSNGYTNEIDVRDSISDFPSEFKDSQDGAYDNG--MQNSVDS 414
            |.:|||:.||                            |.....|...::...|.|  .:|::::
Mouse   358 HKLPKLLCMR----------------------------SHADRYFTQREEAEKDGGPKSRNTLEA 394

  Fly   415 DNVIPRNLTPEVLQALRAVRFIAQHIKDADKDNEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAI 479
                          ||..:|:|.:|:...:...|:||||||::.||||.|||.|.|..:.|||.:
Mouse   395 --------------ALDCIRYITRHVVKENDVREVVEDWKFIAQVLDRMFLWTFLLVSIIGTLGL 445

  Fly   480 ICQSPSLY 487
            ..  |.:|
Mouse   446 FV--PVIY 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	194/453 (43%)
nAChRbeta2	NP_524483.1	LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	91/218 (42%)
Chrna5	NP_001360830.1	LGIC_ECD	45..251	CDD:355788	91/217 (42%)
Chrna5	NP_001360830.1	Neur_chan_memb	257..445	CDD:367256	99/229 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	253	1.000	Domainoid score	I2060
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45250
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.830