Protein Alignment nAChRbeta2 and Chrnb3

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_775304.1
• Gene: Chrnb3 / 108043
• MGIID: 106212
• Length: 464
• Species: Mus musculus
• Alignment Length: 351
• Identity: 75/351 - (21%)
• Similarity: 119/351 - (33%)
• Gaps: 112/351 - (31%)

  Fly    37 SDSDGYLN-IVEMKHLIHEKKCADMPKDLALHLL--KLSDTNNDGRLDFE--EFYKLSLEHPYFL 96
            ||:|..:| .||..:..:.|     ||.|.:..|  |..:....|.:|||  |.|.|.:.
Mouse   272 SDADSGINGEVEYTYGRNMK-----PKVLDIFNLDRKSGEIQVKGLIDFEENEIYSLIIR----- 326

  Fly    97 CEMYIKYCKAVVPKRNDAE----EGDVLDGEYEQSMKLWPPPLMMIIFS--IME--IIFFVIDIV 153
                 ...|.|.|...|.:    ..||.|.:         |.:.:...|  :||  .:..||.::
Mouse   327 -----ASDKGVPPLNTDCQLIIKVEDVNDNK---------PEIQVTSLSNVVMEDAKVGTVISLI 377

  Fly   154 KTQDQNGTSTSGPMATL-----FIYNPHLRHEVWRFLT---------------YMFVHIGF--MH 196
            ...|::.......:.:|     |...|.::..::..:|               .....:|.  :.
Mouse   378 SVSDKDSGINGKVVCSLSDNVPFELKPSIQENMYSLVTKERLDRELVPEYDIKITATDLGNPPLS 442

  Fly   197 LIMNLLVQI---------FLGVALELVHCWWRVALVYLAGVVAGSMGTSLFTPRVFLAGASGGVY 252
            ...::|||:         |....|||          ||  ......|.|:|:  |..:.......
Mouse   443 TYKSMLVQVSDVNDNIPEFSSNPLEL----------YL--TENNPPGASIFS--VSASDKDINEN 493

  Fly   253 ALITAHI---------ATIIMN----------WKQMEYAIVQLFVFLVFCVTDLG-------VSI 291
            |.||.||         .:.:||          .|:.::..|:.|.|.|. .||.|       |::
Mouse   494 AAITYHIIRGGGTHTDMSTVMNINSETGVIHALKRFDFETVKKFHFHVL-ATDSGSPSLSSNVTV 557

  Fly   292 YNSINDPFDKVGYIAH---ASGALAG 314
            ...|.|..|.|..|.:   |:|:..|
Mouse   558 NVFILDQNDNVPVILYPVSANGSAEG 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	75/351 (21%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	51/253 (20%)
		Cys-loop	154..168	CDD:349832	1/13 (8%)
Chrnb3	NP_775304.1	LIC	6..455	CDD:455710	41/206 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	368..387		3/18 (17%)