DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nAChRbeta2 and Chrnb4

DIOPT Version :9

Sequence 1:NP_524483.1 Gene:nAChRbeta2 / 42920 FlyBaseID:FBgn0004118 Length:519 Species:Drosophila melanogaster
Sequence 2:NP_683746.1 Gene:Chrnb4 / 108015 MGIID:87892 Length:495 Species:Mus musculus


Alignment Length:505 Identity:212/505 - (41%)
Similarity:312/505 - (61%) Gaps:74/505 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 ANPDTKRLYDDLL--SNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWFD 88
            ||.:.| |.||||  :.||.||||..::::.:::.|.|.|||||.||.:.|:|||::|:||.|.|
Mouse    23 ANAEEK-LMDDLLNKTRYNNLIRPATSSSQLISIRLELSLSQLISVNEREQIMTTSIWLKQEWTD 86

  Fly    89 YKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKATLKYTGEVFWEPPAIYKSS 153
            |:|.|:...|.||..|.:|::.:|:||||||||.||.|||::.|...::..|.:.|.|||||||:
Mouse    87 YRLAWNSSCYEGVNILRIPAKRVWLPDIVLYNNADGTYEVSVYTNVIVRSNGSIQWLPPAIYKSA 151

  Fly   154 CEMNVEYFPYDEQICFMKFGSWTYNGAQVD--LKHLDQIPGSNLVQVGIDLTEFYLSVEWDILEV 216
            |::.|::||:|:|.|.:||.||||:..::|  ||....|           :.:|..|.||||:.:
Mouse   152 CKIEVKHFPFDQQNCTLKFRSWTYDHTEIDMVLKSPTAI-----------MDDFTPSGEWDIVAL 205

  Fly   217 PATKNEEYYPDTLEP----FSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDSGEKV 277
            |..:       |:.|    :.|:|:...::||.||||:|||:|||.:|.|.:||||||||.|||:
Mouse   206 PGRR-------TVNPQDPSYVDVTYDFIIKRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKM 263

  Fly   278 TLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIHFRSPSTHNM 342
            |||||:|::||.|.||:::|:|||||.:||:||||||||:||:.|:.|||||||:|.||||||.|
Mouse   264 TLCISVLLALTFFLLLISKIVPPTSLDIPLIGKYLLFTMVLVTFSIVTTVCVLNVHHRSPSTHTM 328

  Fly   343 SPLVRKLFLHFMPKLMMMRR-------------TQYTLPDYD--------DSTPSNGYTNEIDVR 386
            :..|::.|||.:|..:.|:|             :|..|...:        .|:|||.|.|.:...
Mouse   329 ASWVKECFLHKLPTFLFMKRPGLEVSPARVPHSSQLHLTTAEATSTSALGPSSPSNLYGNSMYFV 393

  Fly   387 DSISDFPSEFKDSQDGAYDNGMQNSVDSDNV-IPRN--------LTPEVLQALRAVRFIAQHIKD 442
            :.:...|               :::|.|... :||:        ...::.:||..|.|||||::.
Mouse   394 NPVPATP---------------KSAVSSHTAGLPRDARLRSSGRFRQDLQEALEGVSFIAQHLES 443

  Fly   443 ADKDNEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAIICQSPSLYDTRSP 492
            .|:|..::||||||:||:||.|||:|.:.|:.||:.:..  |.|:...:|
Mouse   444 DDRDQSVIEDWKFVAMVVDRLFLWVFVIVCILGTMGLFL--PPLFQIHAP 491

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRbeta2NP_524483.1 LIC 9..479 CDD:273305 209/490 (43%)
LGIC_ECD_nAChR_proto_alpha-like 29..247 CDD:349832 92/225 (41%)
Chrnb4NP_683746.1 LIC 21..483 CDD:273305 209/495 (42%)
Neur_chan_LBD 26..231 CDD:280998 91/223 (41%)
Neur_chan_memb 238..481 CDD:280999 110/257 (43%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D188416at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm11113
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.820

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