Protein Alignment nAChRbeta2 and LOC101882637

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: XP_021324910.1
• Gene: LOC101882637 / 101882637
• -ID: -
• Length: 540
• Species: Danio rerio
• Alignment Length: 496
• Identity: 166/496 - (33%)
• Similarity: 269/496 - (54%)
• Gaps: 58/496 - (11%)

  Fly    32 RLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYKLRWDPE 96
            :|..||..||...:|||.:....:.|.|.:.|||:|:::.:||::||.||::|.|||..|.|:..
Zfish    52 KLLKDLFVNYTSALRPVEDTNNIINVTLQITLSQIIDMDERNQILTTYLWIRQVWFDAYLTWNTT 116

  Fly    97 EYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKATLKYTGEVFWEPPAIYKSSCEMNVEYF 161
            :|.|::.:.:||.::|.||:|||||.|..:..::.|...:::.|::.|:.|||.||||:::|.:|
Zfish   117 DYDGLDTIRIPSSYVWRPDVVLYNNADDQFSSSMETNVVIRHDGQIMWDQPAITKSSCKVDVSFF 181

  Fly   162 PYDEQICFMKFGSWTYNGAQVDLKH-LDQIPGSNLVQVGIDLTEFYLSVEWDILEVPATKNEEYY 225
            |:|.|.|.:.|||||:||.|:||.: ||          ..||.:|..:|||::..:||.||...|
Zfish   182 PFDVQHCRLTFGSWTHNGNQMDLHNALD----------SADLADFVENVEWEVQGMPAKKNVILY 236

  Fly   226 PDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDSGEKVTLCISILVSLTVF 290
            ....:|:.|||:.|.::|:..||..||::||:.::||..|.||||:||||||:|.:::|::||||
Zfish   237 GCCSDPYPDITYTLHLKRRASFYIFNLLIPCMMISFLAPLGFYLPADSGEKVSLGVTVLLALTVF 301

  Fly   291 FLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIHFRSPSTHNMSPLVRKLFLHFMP 355
            .||:||.:|| |..|||:|||.:.||.:::.|...|:.::|||...|....:....|:..|:::.
Zfish   302 QLLVAESMPP-SENVPLIGKYYIATMTMITASTALTIFIMNIHHCGPEAQPVPSWARRFILNYLA 365

  Fly   356 KLMMMRRTQYTLPDYDDSTPS--------NGYTNEID------------VRDSISD------FPS 394
            :...:.....:........|:        ||.....|            |:|..::      .|.
Zfish   366 RFCFVYDMGQSCVSVHTDQPAKKGNNCTINGQARGEDFALRLHEGCSQKVKDQFNEDASPTLSPQ 430

  Fly   395 EFKDSQDG--------------AYDNGMQNSVDSDNVIPRNLTPEV-----LQA-LRAVRFIAQH 439
            :.|:.|.|              |...|...:...::|..|.:..|.     .|| ||.|.:||..
Zfish   431 QRKEHQSGWRIGTFVEIEHGESAGATGETGASRKESVKKREILVESQCLCHQQALLRNVEYIANF 495

  Fly   440 IKDADKDNEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAII 480
            .::.........:|:.|:.|:||||:|:|.:.....:|.||
Zfish   496 YQEQKATQRRNAEWRKVAKVMDRFFMWIFFIMVFLMSLLII 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	164/493 (33%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	84/215 (39%)
		Cys-loop	154..168	CDD:349832	6/13 (46%)
LOC101882637	XP_021324910.1	LGIC_ECD	50..256	CDD:475126	84/213 (39%)
		LGIC_TM_cation	257..>344	CDD:349853	44/87 (51%)
		TM1 helix	257..281	CDD:349853	11/23 (48%)
		Neur_chan_memb	263..535	CDD:460753	77/272 (28%)
		TM2 helix	289..310	CDD:349853	10/20 (50%)
		TM3 helix	320..342	CDD:349853	6/21 (29%)