Protein Alignment nAChRbeta2 and chrna8

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: XP_021329572.1
• Gene: chrna8 / 100537531
• ZFINID: ZDB-GENE-090313-161
• Length: 516
• Species: Danio rerio
• Alignment Length: 491
• Identity: 186/491 - (37%)
• Similarity: 276/491 - (56%)
• Gaps: 41/491 - (8%)

  Fly    31 KRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYKLRWDP 95
            ::||.:|:.|||||.|||:|::..:.|.|||.|.|:|:|:.||||:.||.|::..|.|..|.|:|
Zfish    33 RKLYKELMENYNRLERPVLNDSAPIVVELGLTLLQIIDVDEKNQVLITNAWLQLGWTDVYLSWNP 97

  Fly    96 EEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKATLKYTGEVFWEPPAIYKSSCEMNVEY 160
            :.|.||:.|..||..||.|||:|||:.|..::.|..|...:..:|...:.||.|.||:|.::|.:
Zfish    98 DNYPGVQTLRFPSNQIWTPDILLYNSADERFDATFHTNVLVNASGACQYIPPGILKSTCYIDVRW 162

  Fly   161 FPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDLTEFYLSVEWDILEVPATKNEEYY 225
            ||:|.|.|.:||||||:||..:||:           ...:|::.:..:.|||::.||..:||.||
Zfish   163 FPFDIQKCDLKFGSWTHNGWLLDLQ-----------MQAVDISTYIPNGEWDLVGVPGKRNELYY 216

  Fly   226 PDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDSGEKVTLCISILVSLTVF 290
            ....||:.|:||.:||||:||:|.:||::|||.::.|.:|||.||:|||||::|.|::|:|||||
Zfish   217 ECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISGLALLVFLLPADSGEKISLGITVLLSLTVF 281

  Fly   291 FLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIHFRSPSTHNMSPLVRKLFLHFMP 355
            .||:|||:|.||.:|||:.:|...||::|.|||..||.||..|...|....|...||.:.|::..
Zfish   282 MLLVAEIMPATSDSVPLIAQYFASTMMIVGLSVVVTVLVLQFHHHDPQGGKMPRWVRVILLNWCA 346

  Fly   356 KLMMMRRT--------QY----------------TLPDYDDSTPS--NGYTNEIDVRDSISDF-- 392
            ..:.|::.        :|                .:|....||.|  ||:.|......||...
Zfish   347 WFLRMKKPGEERKANFKYDQSPAHHASASSIQMGVMPGQPSSTNSTTNGHMNLYFGYHSIDSACC 411

  Fly   393 --PSEFKDSQDGAYDNGMQNSVDSDNVIPRNLTPEVLQALRAVRFIAQHIKDADKDNEIVEDWKF 455
              .|:...|..|....|..|....:.|......||:.:.|..|.:|||..:|.|:...|..:|||
Zfish   412 PPSSDSGVSCSGGRVGGSPNEEQREGVRMFAGEPEIHRILAEVMYIAQRFRDQDEAEAICSEWKF 476

  Fly   456 VSMVLDRFFLWLFTLSCVFGTLAIICQSPSLYDTRS 491
            .:.|:||..|..|:|..:..|..|:..:|:..:..|
Zfish   477 AAAVVDRLCLVAFSLFSIICTFTILMSAPNFIEAVS 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	183/477 (38%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	92/215 (43%)
		Cys-loop	154..168	CDD:349832	6/13 (46%)
chrna8	XP_021329572.1	LIC	12..504	CDD:455710	184/481 (38%)