DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRbeta2 and chrng

DIOPT Version :10

Sequence 1:NP_524483.1 Gene:nAChRbeta2 / 42920 FlyBaseID:FBgn0004118 Length:519 Species:Drosophila melanogaster
Sequence 2:NP_001241879.2 Gene:chrng / 100536659 ZFINID:ZDB-GENE-030131-3805 Length:540 Species:Danio rerio


Alignment Length:529 Identity:184/529 - (34%)
Similarity:285/529 - (53%) Gaps:63/529 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MWHWSLLCVFLLVPLANSTAPISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQ 65
            :|.|.||..|       |.|..:.|.:     |:.||:..||:.||||.::.:.:.|.:.:.|:.
Zfish    10 IWLWILLFCF-------SGALCNLEGS-----LHRDLMVAYNKNIRPVESHGDIIDVKIKMTLTN 62

  Fly    66 LIEVNLKNQVMTTNLWVKQRWFDYKLRWDP----EEYGGVEQLYVPSEHIWVPDIVLYNNWDGNY 126
            ||.:|.|.:.:||.:|::.:|.||:|||..    |.|..:.::.:||:.||:|||.|.||.||.:
Zfish    63 LISLNEKEETLTTCVWIEMQWRDYRLRWANRTGFEVYENITRMRLPSKTIWLPDIGLENNVDGRF 127

  Fly   127 EVTLMTKATLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIP 191
            ||.|.....:...|.|:|.|||||:|||.:.|.|||:|.|.|.|.|.|.|||..::.|...|:  
Zfish   128 EVALYANTLIDPDGSVYWLPPAIYRSSCAIKVNYFPFDWQNCSMVFRSQTYNSNEITLMLSDE-- 190

  Fly   192 GSNLVQ--VGIDLTEFYLSVEWDILEVPATK--NEEYYPDTLEPFSDITFKLTMRRKTLFYTVNL 252
             .|:..  :.||...|..:.||.|...||.|  |:.|.||.|| ..:|.|.|.::||.|||.:|:
Zfish   191 -DNVTMEWIEIDPEAFTENGEWMIKHRPAKKVINKRYRPDELE-HQEIIFFLIIQRKPLFYVINI 253

  Fly   253 IVPCVALTFLTVLVFYLPSDS-GEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTM 316
            |||||..:.|.:||::||:.: |:|.|:.|.||:..|||..|:|:.:|.||.||||:||||:|.|
Zfish   254 IVPCVLFSSLGLLVYFLPAKAGGQKCTMTICILLGQTVFLFLIAKKVPETSQAVPLIGKYLMFVM 318

  Fly   317 ILVSLSVWTTVCVLNIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRRTQYTLPDYDD--------- 372
            .:.:::|...|.|||:..|:|:||.||..:||:.|:.:|:::.|...::| |:.::         
Zfish   319 SVTTITVMNCVVVLNVSLRTPNTHPMSNTIRKVLLNILPRVLRMTMQRWT-PEQEEGDFKMFALG 382

  Fly   373 -STP-------SNGYTNEID---VRDSISDFPSEFKDSQDGAYDNGM---QNSVDSDNVIPRNL- 422
             .||       |.|...:.|   .|.:.|:........:.|...|.:   ||.:..:..  ::| 
Zfish   383 NGTPLRRRRRSSLGLIAKADEYMFRTARSELMFSRLKERKGLLKNTLEKIQNGLGGNTA--QDLE 445

  Fly   423 ------TPEVLQALRAVRFIAQHIKDADKDNEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAIIC 481
                  :|||.|.:.:.:.||:..|..:......|:|..|:.|:||...::..|..:.||:.|..
Zfish   446 CSLAAASPEVQQCVSSCKHIAESTKHQNDFQSKNEEWFLVARVIDRMCFFVMALLFILGTIGIFL 510

  Fly   482 -----QSPS 485
                 |:||
Zfish   511 TGHFNQAPS 519

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRbeta2NP_524483.1 LIC 9..479 CDD:455710 176/508 (35%)
LGIC_ECD_nAChR_proto_alpha-like 29..247 CDD:349832 88/225 (39%)
Cys-loop 154..168 CDD:349832 7/13 (54%)
chrngNP_001241879.2 None

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