Protein Alignment nAChRbeta2 and chrnb4

DIOPT Version :9

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: XP_012822341.1
• Gene: chrnb4 / 100497893
• XenbaseID: XB-GENE-985370
• Length: 481
• Species: Xenopus tropicalis
• Alignment Length: 505
• Identity: 220/505 - (43%)
• Similarity: 320/505 - (63%)
• Gaps: 63/505 - (12%)

  Fly    25 EANPDTKRLYDDLL--SNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWF 87
            :|....:||.::||  ..||:||||..||::.:::.|.|.|:|||.||.:.|:||||:|:.|.|.
 Frog    21 KAADSEERLMNNLLRKDKYNKLIRPAYNNSQLVSIQLQLSLAQLISVNEREQIMTTNVWLNQEWV 85

  Fly    88 DYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKATLKYTGEVFWEPPAIYKS 152
            ||:|.|:|.:|.|:::|.:||:.||:||||||||.||.|||:|.|.|.::..|.|.|.|||||||
 Frog    86 DYRLTWNPADYDGIKKLRIPSQQIWLPDIVLYNNADGTYEVSLFTNAIVQNNGSVAWLPPAIYKS 150

  Fly   153 SCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVG-IDLTEFYLSVEWDILEV 216
            :|::.|::||:|:|.|.:||.||||:..::||          ::..| ..:.:|..|.||||:|:
 Frog   151 ACKIEVKHFPFDQQNCTLKFRSWTYDYTEIDL----------VLNKGWATMDDFTPSGEWDIIEL 205

  Fly   217 PATKNEEYYPDTLEP-FSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDSGEKVTLC 280
            |..:.  ..|  |:| :.|:|:...::||.||||:|||:||:.:|.|.:||||||||.|:|:|||
 Frog   206 PGRRT--ICP--LDPTYVDVTYDFIIKRKPLFYTINLIIPCILITSLAILVFYLPSDCGQKMTLC 266

  Fly   281 ISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIHFRSPSTHNMSPL 345
            ||:|::||||.||:::|:|||||.|||:||||:|||:||:.|:.|:|||||:|.||||||.|.|.
 Frog   267 ISVLLALTVFLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMPPW 331

  Fly   346 VRKLFLHFMPKLMMMRRTQYT-----LPDY------DDSTPSNGYTNEIDVR--DSISDFPSEFK 397
            |:..||..:|..:.|:|.:.:     |..|      :....||.:.|....|  |...:.|.|..
 Frog   332 VKNCFLDRLPVFLFMKRPENSSASQKLRSYRRNMQIESFRNSNYFVNMTTARPCDHTVNDPPESV 396

  Fly   398 DSQDGAYDNGMQNSVDSDNVIPRNLTPEVLQALRAVRFIAQHIKDADKDNEIVEDWKFVSMVLDR 462
            ..|:..|.            .||..||||.:|:..|:||::|:|..|:|..|:||||:|:||:||
 Frog   397 RHQEFRYR------------YPRKYTPEVHEAMDGVKFISEHMKSEDEDQSIIEDWKYVAMVVDR 449

  Fly   463 FFLWLFTLSCVFGTLAIICQSPSLYDTRSPIDRQLSEIPLRKNNFMLPPD 512
            .|||:|.:.|:.||:.:..|                  ||.:|:  .|||
 Frog   450 LFLWIFIIVCIVGTVGLFMQ------------------PLIQNH--TPPD 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	213/470 (45%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	97/221 (44%)
chrnb4	XP_012822341.1	LIC	21..468	CDD:273305	213/472 (45%)
		LGIC_ECD	53..230	CDD:355788	83/190 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm14085
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010