DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRbeta2 and chrna6

DIOPT Version :9

Sequence 1:	NP_524483.1	Gene:	nAChRbeta2 / 42920	FlyBaseID:	FBgn0004118	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	XP_031759256.1	Gene:	chrna6 / 100495287	XenbaseID:	XB-GENE-6033398	Length:	488	Species:	Xenopus tropicalis

Alignment Length:	485	Identity:	208/485 - (42%)
Similarity:	315/485 - (64%)	Gaps:	24/485 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 CVFLLVPLANSTAPISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLK 72
            |..||..||.....:..|..   ::|:..||:.||:.||||.|.::.:.|...:.::||:.|:..
Frog    12 CFLLLTLLAVLKGSLQCETE---EKLFQKLLARYNQHIRPVENVSDPVMVHFEVAITQLVNVDEV 73

  Fly    73 NQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKATLK 137
            ||::.||||::..|.||||:|:||||.|:|.:.:|::.||.||||||||..|:::|...:||.:|
Frog    74 NQILETNLWLRHIWNDYKLQWNPEEYDGIEFMRIPADKIWKPDIVLYNNAVGDFQVEGKSKALVK 138

  Fly   138 YTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDL 202
            |.|.:.|.||||:||||.|::.:||:|.|.|.||||||:|:.|::||    .|.||.     :|:
Frog   139 YNGLITWSPPAIFKSSCPMDITFFPFDHQNCSMKFGSWSYDKAKIDL----AIIGSK-----VDM 194

  Fly   203 TEFYLSVEWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVF 267
            .:|:.:.||:|::....|::..|....|.::|||:...:||..:|||:|||:||:.|:|||||||
Frog   195 KDFWENSEWEIVDASGFKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIMPCLFLSFLTVLVF 259

  Fly   268 YLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNI 332
            |||||.|||||||||:|:|||||.|::.|.||.|||.:||:|:|||||||.|:||:..||.||||
Frog   260 YLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLVGEYLLFTMIFVTLSIVVTVFVLNI 324

  Fly   333 HFRSPSTHNMSPLVRKLFLHFMPKLMMMRRT--QYTLPDYDDSTPSNGYTNEIDVRDSISDFPSE 395
            |:|:|:||.|...|:.:||..:|||:||::|  :...| |.............::.||.|....:
Frog   325 HYRTPTTHKMPMWVKDVFLKRLPKLLMMKKTVEKKNRP-YSKQNRKKSCEKSSELVDSESAEVEQ 388

  Fly   396 FKD--------SQDGAYDNGMQNSVDSDNVIPRNLTPEVLQALRAVRFIAQHIKDADKDNEIVED 452
            |:|        |::.:.....:...||:..: :..:.|:.:.:.:::|:|.:|:|.::..|..:|
Frog   389 FEDESCYHCMRSKEQSSRVRRRQQRDSNGAV-QECSSELTEVVDSIQFMAGNIRDHNERKEEEDD 452

  Fly   453 WKFVSMVLDRFFLWLFTLSCVFGTLAIICQ 482
            ||:|:||:||.|||:|.|.||.||..:..|
Frog   453 WKYVAMVIDRVFLWVFILLCVVGTTGLFLQ 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	206/479 (43%)
nAChRbeta2	NP_524483.1	LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	91/217 (42%)
chrna6	XP_031759256.1	LIC	29..481	CDD:273305	202/465 (43%)
chrna6	XP_031759256.1	LGIC_ECD	31..237	CDD:355788	91/217 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2037
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	1	1.000	-	-		FOG0000583
OrthoInspector	1	1.000	-	-		mtm14085
Panther	1	1.100	-	-	O	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X294
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.110