Protein Alignment nAChRbeta2 and chrna9

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: XP_012811629.2
• Gene: chrna9 / 100493319
• XenbaseID: XB-GENE-983401
• Length: 494
• Species: Xenopus tropicalis
• Alignment Length: 502
• Identity: 180/502 - (35%)
• Similarity: 279/502 - (55%)
• Gaps: 44/502 - (8%)

  Fly     6 LLCVFLLVPLANSTAPISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVN 70
            |..||:|:.|..    :........:.|:.||..:|:..:|||.:..:.|.|.|.:.|||:.:|:
 Frog    12 LFHVFVLLDLKG----VESAKGKYAQMLFRDLFEDYSNALRPVEDTDKALNVSLQITLSQIKDVD 72

  Fly    71 LKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKAT 135
            .:||::|..||::..|:|..|:||.:||.|::.:.:||..:|.|||||||..|..:...:.|...
 Frog    73 ERNQILTAYLWIRLSWYDAYLKWDRDEYDGLDSIRIPSNMVWRPDIVLYNKADDEFSEPVNTNVV 137

  Fly   136 LKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGI 200
            |:|.|::.|:.|||.||||.::|.|||:|.|.|.:.||||||||.|||:        .|.:..|
 Frog   138 LRYDGKITWDSPAITKSSCVVDVSYFPFDNQQCNLTFGSWTYNGNQVDI--------INTMDSG- 193

  Fly   201 DLTEFYLSVEWDILEVPATKNEEYYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVL 265
            ||::|..:|||::..:||.||...|....||:.||||.|.::|::.||..||::|||.::||..|
 Frog   194 DLSDFVENVEWEMQGMPAVKNVITYGCCSEPYPDITFTLILKRRSSFYIFNLLIPCVMISFLAPL 258

  Fly   266 VFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVL 330
            .||||:||||||:|.:::|::||||.|::||.:|| |.:|||:|||.:.||.:::.|...|:.::
 Frog   259 GFYLPADSGEKVSLGVTVLLALTVFQLMVAESMPP-SESVPLIGKYYIATMTMITASTALTIIIM 322

  Fly   331 NIHFRSPSTHNMSPLVRKLFLHFMPKLMMMRRT--QYTLPDYDDSTPSNGYTNEIDVRDSISDFP 393
            |||...|....:....|.:.|.:|.|:..:...  ..|.|..|..|.|||..      .|..|:.
 Frog   323 NIHLCGPEAKPIPRWARIVILDYMSKIFFVYDVGENCTSPQSDSDTKSNGSV------PSYEDYE 381

  Fly   394 SEFKD-SQDGAYDNGMQN-SVDSDNVIPRN--------LTPEVLQA--------LRAVRFIAQHI 440
            .|.:. |..|...:|..| |.|.|.....|        |..|:.:.        .|.:....::|
 Frog   382 KEQEPYSSLGCPLSGSGNFSCDIDTNKKLNGHLGGHYALQKEISETHCCAHCNRYRVLTNNIEYI 446

  Fly   441 KDADKDNEIVE----DWKFVSMVLDRFFLWLFTLSCVFGTLAIICQS 483
            .:..::.:.:.    :||.|:.|:||||:|:|.....|.::.||.|:
 Frog   447 TNWYREQKAISAKGIEWKKVAKVMDRFFMWVFFSMVFFMSILIIAQA 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	176/493 (36%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	89/217 (41%)
		Cys-loop	154..168	CDD:349832	7/13 (54%)
chrna9	XP_012811629.2	LIC	5..486	CDD:455710	177/493 (36%)
		LGIC_ECD_nAChR_A9	32..238	CDD:349823	89/214 (42%)
		Cys-loop	156..170	CDD:349823	7/13 (54%)