Protein Alignment nAChRbeta2 and gabrr3

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: XP_017947352.2
• Gene: gabrr3 / 100487991
• XenbaseID: XB-GENE-6039478
• Length: 481
• Species: Xenopus tropicalis
• Alignment Length: 300
• Identity: 59/300 - (19%)
• Similarity: 130/300 - (43%)
• Gaps: 35/300 - (11%)

  Fly    38 LSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYKLRWDPEE----- 97
            :.:::..:||....: .:.|.:.:::..:..::..:...|..|:::..|.|.:|.:....
 Frog    83 IDDHDFAMRPGFGGS-AIPVGIDVQIESIDSISEVDMDFTMTLYLRHYWKDERLSFQSTNNRSMT 146

  Fly    98 YGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKATLKY--TGEVFWEPPAIYKSSCEMNVEY 160
            :.|  :|.   :.|||||:...::.......|.|....|:.  .|.|.:.......:.|.|:...
 Frog   147 FDG--RLI---KKIWVPDVFFVHSKRSFIHDTTMENIMLRVYPDGNVLFSLRITVTAMCFMDFSR 206

  Fly   161 FPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVG--IDLTEFYLSVEWDILEVPATKNEE 223
            ||.|.|.|.::..|:.||  :.||. |....|:..::..  |.|::|::.      |..|:....
 Frog   207 FPLDTQNCSLELESYAYN--EEDLM-LYWKRGNESLKTDEHIALSQFFIE------EFSASNGLA 262

  Fly   224 YYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYL-----PSDSGEKVTLCISI 283
            :|..| ..::.:.....:||...|:.:....|.:.:..|:.:.|::     |:    :|:|.|:.
 Frog   263 FYSST-GWYNRLFINFILRRHIFFFLLQSYFPAMLMVMLSWVSFWIDRRAVPA----RVSLGITT 322

  Fly   284 LVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSV 323
            :::::.....::..:|..|. :..:..||..:.:.|.|||
 Frog   323 VLTMSTIITGVSASMPQVSY-IKAVDVYLWISFLFVFLSV 361

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	58/299 (19%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	43/217 (20%)
		Cys-loop	154..168	CDD:349832	6/13 (46%)
gabrr3	XP_017947352.2	LIC	77..480	CDD:455710	58/299 (19%)
		LGIC_ECD	98..283	CDD:475126	41/199 (21%)