Protein Alignment nAChRbeta2 and chrnb3

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: XP_002942943.1
• Gene: chrnb3 / 100379831
• XenbaseID: XB-GENE-5793509
• Length: 460
• Species: Xenopus tropicalis
• Alignment Length: 451
• Identity: 205/451 - (45%)
• Similarity: 287/451 - (63%)
• Gaps: 37/451 - (8%)

  Fly    37 LLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGV 101
            |.:.|.:.:|||:|...|:.|..|||:|||::|:.|.|:||||:|::|.|.|.||||:|::|||:
 Frog    38 LFAGYQKWVRPVLNPNSTIKVNFGLKISQLVDVDEKKQLMTTNVWLRQEWMDMKLRWNPKDYGGI 102

  Fly   102 EQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKATLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQ 166
            ..:.||||.:|:|||||:.|.||.:|.:|||||.:||.|.|.|.|||.|||||.|:|.:||:|.|
 Frog   103 TYIRVPSESLWLPDIVLFENADGRFEGSLMTKAIIKYDGTVTWTPPASYKSSCTMDVTFFPFDRQ 167

  Fly   167 ICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDLTEFYLSVEWDILEVPATKNEEYYPDTLEP 231
            .|.||||||||:|..|||..||:         .:|..:|:.:.|||||.....|...  .|.|..
 Frog   168 NCSMKFGSWTYDGNMVDLILLDE---------NVDRKDFFDNGEWDILNATGLKGMR--KDGLYS 221

  Fly   232 FSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAE 296
            :..||:...:||..||||:.||:||:.|:||||||||||||.|||::|..|:|||||||.|::.|
 Frog   222 YPFITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEE 286

  Fly   297 IIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIHFRSPST-HNMSPLVRKLFLHFMPKLMMM 360
            |||.:|..:||:|:||||.||.|:||:..||.|:|:|.||.:| |.|:|.|::|||..:|||:.|
 Frog   287 IIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSATYHPMAPWVKRLFLEKLPKLLCM 351

  Fly   361 RRTQYTLPDYDDSTPSNGYTNEIDVRDSISDFPSEFKDSQDGAYDNGMQNSVDSDNVIPRNLTPE 425
            :                |:.:.....||.||. |..|....|...|  .::.|.:.|:...|.
 Frog   352 K----------------GHVDRFSFFDSESDV-SSAKSKPSGKRKN--IHASDGEKVLIAFLE-- 395

  Fly   426 VLQALRAVRFIAQHIKDADKDNEIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAIICQSPSL 486
              :|..::::|:.|:|......::|:|||||:.||||.|||||....:.|::.|.  :|:|
 Frog   396 --KAADSIKYISTHVKKEHFIRQVVQDWKFVAQVLDRIFLWLFLSVSITGSVLIF--TPAL 452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	202/442 (46%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	100/209 (48%)
		Cys-loop	154..168	CDD:349832	7/13 (54%)
chrnb3	XP_002942943.1	LIC	2..451	CDD:455710	203/448 (45%)
		LGIC_ECD_nAChR_B3	56..234	CDD:349827	92/188 (49%)
		Cys-loop	155..169	CDD:349827	7/13 (54%)