Protein Alignment nAChRbeta2 and chrna5

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: XP_002937929.1
• Gene: chrna5 / 100379824
• XenbaseID: XB-GENE-5755296
• Length: 476
• Species: Xenopus tropicalis
• Alignment Length: 482
• Identity: 201/482 - (41%)
• Similarity: 292/482 - (60%)
• Gaps: 66/482 - (13%)

  Fly     4 WSLLCVFLLVPLANSTAPISFEANPDTKRLYDDLL--SNYNRLIRPVVNNTETLTVWLGLKLSQL 66
            |..||:.:|......:.|.....:.|  ||:..|.  .:|.|.:|||.:..:|:.|..||.::||
 Frog    25 WLFLCLDILHGACGISEPSYIAKSED--RLFKYLFQQQDYQRWVRPVEHLNDTVKVKFGLAITQL 87

  Fly    67 IEVNLKNQVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLM 131
            ::|:.|||:||||:|:||.|.|.||||||.|:.|:..:.|||:.||:||||||:|.||.:|.: :
 Frog    88 VDVDEKNQLMTTNVWLKQEWVDVKLRWDPNEFAGITSIRVPSDSIWIPDIVLYDNADGRFEGS-V 151

  Fly   132 TKATLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLV 196
            |||.::|.|.:.|.|||.|||||.::|.:||:|.|.|.||||||||:|:|||:         .|.
 Frog   152 TKAVVRYDGTINWTPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDI---------ILE 207

  Fly   197 QVGIDLTEFYLSVEWDILEVPATKNEE-----YYPDTLEPFSDITFKLTMRRKTLFYTVNLIVPC 256
            ...:|..:|:.:.||:|:.....|...     :||       .||:...::|..||||:.||:||
 Frog   208 DYHVDKRDFFDNGEWEIVNATGNKGNRTDGCCFYP-------YITYSFIIKRLPLFYTLFLIIPC 265

  Fly   257 VALTFLTVLVFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSL 321
            :.|:|||:|||||||:.|||::||.|:|||||||.|::.||||.:|..:||:|:||:||||.|:|
 Frog   266 IGLSFLTILVFYLPSNEGEKISLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTL 330

  Fly   322 SVWTTVCVLNIHFRSPSTHN-MSPLVRKLFLHFMPKLMMMRRTQYTLPDYDDSTPSNGYTNEIDV 385
            |:..||..:|||.||.:||| |:|.|||:|||.:|||:.||                   :.:|.
 Frog   331 SIVLTVFAINIHNRSSATHNAMAPWVRKIFLHKLPKLLCMR-------------------SHVDR 376

  Fly   386 RDSISDFPSEFKDSQDGAYDNGMQNSVDSDNVIPRNLTPEVLQALRAVRFIAQHIKDADKDNEIV 450
            ..:..|...:.:..:..      :|::::              ||.::|:|.:|:....:..|:|
 Frog   377 YFTRKDETGKVRGPESS------RNTLEA--------------ALDSIRYITRHVMKEHEVQEVV 421

  Fly   451 EDWKFVSMVLDRFFLWLFTLSCVFGTL 477
            ||||||:.||||.|||.|.|..|.|:|
 Frog   422 EDWKFVAQVLDRMFLWTFLLVSVIGSL 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	198/477 (42%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	95/224 (42%)
		Cys-loop	154..168	CDD:349832	6/13 (46%)
chrna5	XP_002937929.1	LIC	19..453	CDD:455710	201/482 (42%)
		LGIC_ECD_nAChR_A5	47..255	CDD:349819	95/226 (42%)
		Cys-loop	174..188	CDD:349819	6/13 (46%)