Protein Alignment nAChRbeta2 and chrna1

DIOPT Version :10

• Sequence 1: NP_524483.1
• Gene: nAChRbeta2 / 42920
• FlyBaseID: FBgn0004118
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: XP_002934647.1
• Gene: chrna1 / 100145177
• XenbaseID: XB-GENE-977139
• Length: 457
• Species: Xenopus tropicalis
• Alignment Length: 478
• Identity: 199/478 - (41%)
• Similarity: 293/478 - (61%)
• Gaps: 48/478 - (10%)

  Fly     9 VFLLVPLANSTAPISFEANPDTKRLYDDLLSNYNRLIRPVVNNTETLTVWLGLKLSQLIEVNLKN 73
            :||.:     .|.:.| ::.|..||.:||..:||:::|||....:.:.|.|||:|.|||.|:..|
 Frog     9 IFLFI-----AATLVF-SSEDESRLINDLFKSYNKVVRPVKAFKDKVVVTLGLQLIQLINVDEVN 67

  Fly    74 QVMTTNLWVKQRWFDYKLRWDPEEYGGVEQLYVPSEHIWVPDIVLYNNWDGNYEVTLMTKATLKY 138
            |::|||:.:||:|.|..|:|:||:|||::::.:.|..||.||||||||.||::.:...||..|.|
 Frog    68 QIVTTNVRLKQQWEDVHLKWNPEDYGGIKKVRISSGDIWRPDIVLYNNADGDFAIVQETKVLLDY 132

  Fly   139 TGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDLT 203
            ||::.|.||||:||.|||.|.|||:|.|.|.||.|:|||:|:.|.:......|         ||:
 Frog   133 TGKIIWTPPAIFKSYCEMIVTYFPFDLQNCSMKLGTWTYDGSLVVINPESDRP---------DLS 188

  Fly   204 EFYLSVEWDILEVPATKNEEYY---PDTLEPFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVL 265
            .|..|.||.:.:....|:..||   |:|  |:.|||:...::|..|::.||:::||:..:|||.|
 Frog   189 NFMESGEWYMKDYRGWKHWVYYDCCPET--PYLDITYHFLLQRLPLYFIVNVVIPCLLFSFLTGL 251

  Fly   266 VFYLPSDSGEKVTLCISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLSVWTTVCVL 330
            |||||:|||||:||.:|:|:||.||.|::.|:||.||.||||:|||:||||:.|..|:..||.|:
 Frog   252 VFYLPTDSGEKITLSVSVLLSLVVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVITSIVITVIVI 316

  Fly   331 NIHFRSPSTHNMSPLVRKLFLHFMPKLM----MMRRTQYTLPDYDDSTPSNGYTNEIDVRDSISD 391
            |.|.||||||.|...::|:|:..:|::|    |.|..|       |......:|.:||    |||
 Frog   317 NTHHRSPSTHIMPQWLKKIFIETIPRVMFFSTMKRPAQ-------DQQKKKIFTEDID----ISD 370

  Fly   392 FPSEFKDSQDGAYDNGMQNSVDSDNVIPRNLTPEVLQALRAVRFIAQHIKDADKDNEIVEDWKFV 456
            ...:...:           :|...:.|.:|  |:|..|:...::||:.:|...:.|:..|:||||
 Frog   371 ISGKLGPA-----------AVKYQSPILKN--PDVKSAIEGAKYIAETMKSDQESNKASEEWKFV 422

  Fly   457 SMVLDRFFLWLFTLSCVFGTLAI 479
            :||||...|.:|.:.|:.|||||
 Frog   423 AMVLDHLLLAVFMIVCIIGTLAI 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:455710	197/476 (41%)
		LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	96/220 (44%)
		Cys-loop	154..168	CDD:349832	9/13 (69%)
chrna1	XP_002934647.1	LIC	21..447	CDD:455710	195/460 (42%)
		LGIC_ECD_nAChR_A1	22..231	CDD:349815	96/219 (44%)
		Cys-loop	148..162	CDD:349815	9/13 (69%)